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Search Thermo Fisher Scientific
Invitrogen
Highest antigen sequence indentity to the following orthologs: Mouse (95%), Rat (95%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-140340. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. NCBE (SLC4A10) is a member of the SLC4 family of bicarbonate transporters, several of which play important roles in intracellular-pH regulation and transepithelial HCO(3)(-) transport. The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B. SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted expression pattern. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NBCN2; NCBE; Sodium-Driven Chloride Bicarbonate Exchanger; Solute carrier family 4 member 10; solute carrier family 4, sodium bicarbonate cotransporter-like, member 10; solute carrier family 4, sodium bicarbonate transporter, member 10
Gene Aliases: NBCN2; NCBE; SLC4A10
UniProt ID: (Human) Q6U841
Entrez Gene ID: (Human) 57282
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