Shop All Single-Use BioProcessing Systems

HyPerforma™ Smartainer™ Hardware, 200L, Stainless steel outer container (Thermo Scientific™)

The 200L Thermo Scientific™ HyPerforma™ Smartainer is a stainless-steel non-jacketed outer container system designed to accommodate large volume bioprocess containers.

Features:
• Durable containers are constructed from 304 stainless steel
• Ideal for in-house handling applications in critical areas
• Movable and stackable with pallet jack or forklift
• Non-jacketed
• Allow both top and bottom discharge from BPCs

HyPerforma™ 5:1 Single-Use Bioreactor, 304, jacketed, AC motor, load cells (Thermo Scientific™)

The Thermo Scientific HyPerforma 5:1 Single-Use Bioreactor (S.U.B.), 304, water-jacketed, AC motor, with load cells, is designed using traditional stainless steel bioreactor principles to ensure optimal cell culture performance. The S.U.B. is a fully functional bioreactor vessel that includes single-use sterile contact surfaces for mixing, venting, sparging, and temperature sensing. The complete line of S.U.B.s includes 50, 100, 250, 500, 1,000 and 2,000 L sizes that ensure consistent scalability from pilot-scale studies to pre-clinical studies to commercial production.

HyPerforma Single-Use Bioreactor features include:
• Unique proprietary mixing system that enables conventional overhead mixing while maintaining sterility and integrity of the S.U.B. bioprocess container (BPC)
• Largest qualified standard component library that allows for customization of S.U.B. BPCs
• Minimized vessel footprint and reduced hold-up volumes
• Load cells offered as standard feature with analog or digital communication options
• Option to use industry-leading single-use and traditional sensors for pH, DO, and pressure monitoring
• Updated 5:1 mixing turn-down ratio in combination with patented cross-flow sparger technology introduces gas just above liquid surface to facilitate efficient mass transfer CO2 stripping and reduce bubble sparging and associated foam damage to cells. This enables the use of fewer vessels, which improves productivity and reduces costs simultaneously.

Applications
• Suspension and adherent cell culture processes
• Fermentation processes
• PD scale to full cGMP manufacturing workflows

HyPerforma™ Glass Bioreactor, 240 V, heat and cool, with scale (Thermo Scientific™)

The Thermo Scientific HyPerforma Glass Bioreactor offers easy operation and rapid assembly and is manufactured with the highest standards for materials and surface finish. Developed using a computational fluid dynamics (CFD) simulator, the HyPerforma Glass Bioreactor impellers provide maximum mixing with minimum shear force, resulting in a higher average kLa. The cold finger has been replaced by a cooling loop to increase the thermal surface. Laboratory performance tests have demonstrated a cooling rate two times better than a sample of products from other suppliers. Control can be bidirectional, which allows a single-wall vessel to be used for mammalian applications and fermentation processes.

HyPerforma Glass Bioreactor features include:
• The motor adapter uses coupling windows and an alignment marker for easy assembly
• Ergonomic head plate design provides easy assembly and disassembly of components for rapid reconfiguration

Applications
• Suspension and adherent cell culture processes
• PD scale to full cGMP manufacturing workflows

HyPerforma™ Smartainer™ BPC Hoist, 1500L Smartainer System (Thermo Scientific™)

The Thermo Scientific™ HyPerforma™ BPC Hoist assists in handling and loading large volume bioprocess containers into Smartainer systems. Made of stainless still this is intended for use with the 2000L Smartainer II system.

HyPerforma™ Smartainer™ Hardware, 1000L, Stainless steel outer container (Thermo Scientific™)

The 1000L Thermo Scientific™ HyPerforma™ Smartainer is a stainless-steel non-jacketed outer container system designed to accommodate large volume bioprocess containers.

Features:
• Durable containers are constructed from 304 stainless steel
• Ideal for in-house handling applications in critical areas
• Movable and stackable with pallet jack or forklift
• Non-jacketed
• Allow both top and bottom discharge from BPCs

HyPerforma™ Process Development Automation Package, for 1-2 G3Lab Controller Systems (Thermo Scientific™)

The Thermo Scientific HyPerforma Automation Packages are specifically designed for PD scale bioprocessing applications. The system features Thermo Scientific TruBio software that facilitates easy, reliable, and repeatable process development cell culture processes.

HyPerforma PD Automation Package features include:
• Open architecture capabilities to integrate with vessels from other suppliers (Sartorius, Eppendorf, Millipore,and Applikon)
• The ability to build and manage complex, multi-feed dosing strategies that provide for third-party peripheral integration as needed

Applications
• Suspension and adherent cell culture processes
• Fermentation processes
• PD scale to full cGMP manufacturing workflows

HyPerforma™ Commercial Automation Package, for 3 G3Lite Controller Systems (Thermo Scientific™)

The Thermo Scientific HyPerforma GMP Automation Packages can be integrated with any single-use bioreactor such as the Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) (available in sizes ranging from 50 L to 2,000 L). The system features Thermo Scientific TruBio software that facilitates easy, reliable, and repeatable process development and commercial cell culture processes.

HyPerforma GMP Automation Package features include:
• Open architecture capabilities to integrate with vessels from other suppliers (Sartorius, Eppendorf, Millipore,and Applikon)
• The ability to build and manage complex, multi-feed dosing strategies that provide for third-party peripheral integration as needed

Applications
• Suspension and adherent cell culture processes
• Fermentation processes
• GMP manufacturing workflows

HyPerforma™ 5:1 Single-Use Bioreactor, 304, jacketed, AC motor, load cells, cable management tree (Thermo Scientific™)

The Thermo Scientific HyPerforma 5:1 Single-Use Bioreactor (S.U.B.), 304, water-jacketed, AC motor, with load cells, is designed using traditional stainless steel bioreactor principles to ensure optimal cell culture performance. The S.U.B. is a fully functional bioreactor vessel that includes single-use sterile contact surfaces for mixing, venting, sparging, and temperature sensing. The complete line of S.U.B.s includes 50, 100, 250, 500, 1,000 and 2,000 L sizes that ensure consistent scalability from pilot-scale studies to pre-clinical studies to commercial production.

HyPerforma Single-Use Bioreactor features include:
• Unique proprietary mixing system that enables conventional overhead mixing while maintaining sterility and integrity of the S.U.B. bioprocess container (BPC)
• Largest qualified standard component library that allows for customization of S.U.B. BPCs
• Minimized vessel footprint and reduced hold-up volumes
• Load cells offered as standard feature with analog or digital communication options
• Option to use industry-leading single-use and traditional sensors for pH, DO, and pressure monitoring
• Updated 5:1 mixing turn-down ratio in combination with patented cross-flow sparger technology introduces gas just above liquid surface to facilitate efficient mass transfer CO2 stripping and reduce bubble sparging and associated foam damage to cells. This enables the use of fewer vessels, which improves productivity and reduces costs simultaneously.

Applications
• Suspension and adherent cell culture processes
• Fermentation processes
• PD scale to full cGMP manufacturing workflows

HyPerforma™ G3Lab Controller, for HyPerforma Rocker and Single-Use Bioreactors (non-GMP) (Thermo Scientific™)

The Thermo Scientific G3Lab Controller has been specifically designed for PD scale bioprocessing applications. It can control most brands of single-use or autoclavable bioreactors or fermentors with a capacity of ≤50 L, including stirred-tank and rocking models. The controller operates using proprietary Thermo Scientific TruBio software, which provides easy process scale-up/scale-down and the configurability to scale your control strategy along with your process. The enclosure contains state-of-the-art transmitters along with power supplies, pumps, input/output (I/O) modules, and the hardware required to connect to the control network, providing maximum control capability.

G3Lab Controller features include:
• Open architecture capabilities to integrate with vessels from other suppliers (Sartorius, Eppendorf, Millipore, and Applikon)
• A common control platform throughout a product’s life cycle
• Flexible upstream TruBio software powered by the Emerson™ DeltaV™ system
• Nonproprietary, industry-standard, cGMP-validated (with validation package) distributed control system (DCS) that provides networked multiple-vessel control capability

Applications
• Suspension and adherent cell culture processes
• PD scale to full cGMP manufacturing workflows

HyPerforma™ Glass Bioreactor, 240 V, heat and cool (Thermo Scientific™)

The Thermo Scientific HyPerforma Glass Bioreactor offers easy operation and rapid assembly and is manufactured with the highest standards for materials and surface finish. Developed using a computational fluid dynamics (CFD) simulator, the HyPerforma Glass Bioreactor impellers provide maximum mixing with minimum shear force, resulting in a higher average kLa. The cold finger has been replaced by a cooling loop to increase the thermal surface. Laboratory performance tests have demonstrated a cooling rate two times better than a sample of products from other suppliers. Control can be bidirectional, which allows a single-wall vessel to be used for mammalian applications and fermentation processes.

HyPerforma Glass Bioreactor features include:
• The motor adapter uses coupling windows and an alignment marker for easy assembly
• Ergonomic head plate design provides easy assembly and disassembly of components for rapid reconfiguration

Applications
• Suspension and adherent cell culture processes
• PD scale to full cGMP manufacturing workflows

Three60™ Sampling System BioProcess Container (BPC) (Thermo Scientific™)

The simple design behind the Thermo Scientific™ Three60™ Sampling System allows you to take a representative sample of your product with minimal effort. The fluid path of the pre-irradiated BioProcess Container (BPC) has a quick-turn valve and pinch-and-cut disconnections for fluid transfer and removal. The 250 mL Three60 Sampling System BPC is composed of Thermo Scientific™ ASI™ 77 film, a 5-layer, 7 mL, polyethylene film and includes 2 ports (1 luer lock insert + cap, 1 injection site).

Features of the system include:
• Compatible with a 3.8 cm (1.5-inch) sanitary connector
• Requires no expensive hardware
• Each Three60 package contains a valve and four assemblies with pinch-and-cut disconnections
• Helps to eliminate post-use cleaning steps required with reusable containers, and to reduce cross-contamination risks

Customize standard BPC systems for optimized single-use technology
Choose from the industry’s largest component library, with over 2,000 unique components that include:
• Fittings—straight, reducing, elbow, T-style, X-style, and cross-style
• Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, and steam-to and steam-through connectors
• Filters (used for bioburden reduction)—sterilization grade filters and vent filters
• Tubing—thermoplastic elastomers and platinum-cured silicone
• Sample ports—septum-style and needle-free ports
• Clamps—sliders, pinch, and crimp bands

HyPerforma™ Single-Use Bioreactor, 120 V, heat only (Thermo Scientific™)

The 3 L Thermo Scientific HyPerforma Single-Use Bioreactor has been designed for cell culture process development in both R&D and non-GMP applications. It is easy to set up and operate and constructed with durable materials. The embedded sensor’s optical reader is easily attached and connected to the controller for instant vessel recognition by TruBio software.

HyPerforma Single-Use Bioreactor features include:
• Shipped gamma-irradiated and ready for use
• Optional heating blanket—includes bi-metallic temperature limiting switch embedded in the blanket to help protect against overheating or fires
• Vessel is equipped with pH and dissolved oxygen (DO) sensor reader
• Latex-free, phthalate-free, BPA-free, animal component–free materials

Applications
• Suspension and adherent cell culture processes
• PD scale

Three60™ Sampling System (Thermo Scientific™)

The Thermo Scientific™ Three60™ Sampling System allows you to take a representative sample of your product with minimal effort. The fluid paths of the four pre-irradiated BioProcess Containers (BPCs) and assemblies feature quick-turn valves and pinch-and-cut disconnections for fluid transfer and removal. The 100 mL Three60 Sampling System is composed of Thermo Scientific™ ASI™ 77 film, a 5-layer, 7 mL, polyethylene film and includes 2 ports (1 luer lock insert + cap, 1 injection site).

Features of the system include:
• Compatible with a 3.8 cm (1.5-inch) sanitary connector
• Requires no expensive hardware
• Each Three60 package contains a valve and four assemblies with pinch-and-cut disconnections
• Helps to eliminate post-use cleaning steps required with reusable containers, and to reduce cross-contamination risks

Customize standard BPC systems for optimized single-use technology
Choose from the industry’s largest component library, with over 2,000 unique components that include:
• Fittings—straight, reducing, elbow, T-style, X-style, and cross-style
• Connectors—quick connectors/disconnectors, aseptic connectors and disconnectors, and steam-to and steam-through connectors
• Filters (used for bioburden reduction)—sterilization grade filters and vent filters
• Tubing—thermoplastic elastomers and platinum-cured silicone
• Sample ports—septum-style and needle-free ports
• Clamps—sliders, pinch, and crimp bands

Plastic Drum, 300L, for HyPerforma™ Single-Use Mixer DS 300 (Thermo Scientific™)

The 300L Plastic Drum with Conical Insert adds speed and convenience to your workflow. The drum is designed for use with the Thermo Scientific™ HyPerforma™ Single-Use Mixer (S.U.M.) DS 300 and is easily moved to cold rooms for storage.

Key features:
• Standard plastic drums available in 50, 100, 200, and 300L sizes
• Lightweight for ease of mobility
• Applicable to open- and closed-top mixing applications
• Economical
• Bottom drain for easy transfer
• 5:1 turn down ratio in conjunction with docking station and a bioprocess container bag or liner

Optional:
• Dollies for the drums are available in two sizes: one for 50 to 200L drums and another for 300L drums. These drums should be used with the corresponding optional drum positioner that is available with the docking station.

Required accessories:
• HyPerforma Single-Use Mixer DS 300 docking station
• HyPerforma Single-Use Mixer DS 300 bioprocess container bags for closed-top mixing or liners for open-top mixing

Recommended for:
• Powder-liquid or liquid-liquid mixing applications in single-use
• High-throughput mixing and storage

HyPerforma™ Smartainer™ BPC Hoist, 2000L Smartainer System (Thermo Scientific™)

The Thermo Scientific™ HyPerforma™ BPC Hoist assists in handling and loading large volume bioprocess containers into Smartainer systems. Made of stainless still this is intended for use with the 1500L Smartainer II system.