Search
Integrated Cryo-EM data management software
Thermo Scientific CryoFlow Software bridges data acquisition and downstream analysis for single particle analysis and cryo-electron tomography (cryo-ET) workflows. Integrated into Thermo Scientific Krios, Glacios, Tundra Cryo-TEMs, CryoFlow Software enables quality assessment, live export, hierarchical data organization, and advanced reporting. It helps reduce manual work, increases confidence in your datasets, and accelerates your path from microscope to discovery.
Key capabilities
How CryoFlow Software fits into cryo-EM workflows
CryoFlow Software is not just part of the cryo-EM workflow, it’s what makes the workflow possible.
It enables and connects seamlessly to Thermo Scientific Smart EPU Software and the Thermo Scientific CryoTomo Software Suite, allowing you to efficiently acquire, analyze, and manage micrographs so that only high-quality data is delivered for downstream processing.
CryoFlow Software is fully integrated with Thermo Scientific Tundra, Glacios, and Krios Cryo-Transmission Electron Microscopes (Cryo-TEMs):
Frequently asked questions about CryoFlow Software
Q: What are the hardware requirements and setup process for CryoFlow Software?
A: CryoFlow Software requires a dedicated server, known as a data management platform (DMP), which is connected to the microscope and your institution's infrastructure. During the installation phase, the DMP is configured according to the applications requested and is connected to the network. If additional hardware components such as GPUs, RAM memory, or NVMe SSD are needed, they are included in the relevant offer and installed by the Thermo Fisher Field Service Engineer (FSE). Once installed, the DMP acts as an enhanced tool for temporary hosting, processing, and exporting of experimental data.
Q: What will happen to customers who are currently using Thermo Scientific Athena Software for Life Sciences?
A: Customers currently using Athena Software for Life Sciences will be seamlessly transitioned to the CryoFlow Software platform. This upgrade will be performed by the Thermo Fisher Scientific Field Service Engineer following a standard software update procedure.
Q: How many users can access CryoFlow Software simultaneously?
A: CryoFlow Software supports access for up to 15 users at the same time.
Q: Can CryoFlow Software support multiple cameras?
A: Yes, CryoFlow Software can support up to three cameras on the same microscope.
Q: How is the data protected in case of disk failure?
A: The DMP server, which hosts the data, has a RAID 6 architecture to prevent data loss in case of disk failure.
Q: Who can provide support for the integration of CryoFlow Software and the DMP into our institution's infrastructure?
A: The Digital Solutions Engineer (DSE) team at Thermo Fisher Scientific can assist with this.
Q: Can the DMP server be accessed by users outside the hosting institution's network?
A: Yes, it is technically possible, but it is the responsibility of the hosting institution's IT department to provide controlled access (i.e., via VPN) and to implement regular security patches provided by Thermo Fisher Scientific.
Resources
Webinar: Introduction to CryoFlow Software
Learn how CryoFlow Software automates live monitoring of cryo-EM data collection to reduce hands-on time, facilitating efficient data management and connectivity for downstream processing workflows. We share how the software’s dedicated hardware server enables robust performance and how the web-based user interface helps deliver secure data access, visualization, and remote collaboration.
In this webinar, you will learn how CryoFlow Software:
- Helps provide fast data access and visualization of cryo-EM, single particle analysis, and cryo-ET results.
- Facilitates rapid, reliable feedback on sample quality to optimize data collection and streamline processing.
- Supports secure data sharing for collaborative projects.
Product documentation
Discover what’s new in CryoFlow Software
For Research Use Only. Not for use in diagnostic procedures.