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Pharmaceutical companies use a rapid, iterative process for drug discovery. Structure-based drug design can add important information to evaluate structure-activity relationships for drug compounds throughout hit and lead optimization. This minimizes the number of compounds that must be synthesized and can help accelerate the path to high-efficacy drugs. Many targets of interest to pharma pose challenges for traditional structure determination techniques, like X-ray crystallography or NMR. Cryo-election microscopy (cryo-EM) single particle analysis (SPA) allows you to visualize difficult-to-crystallize molecules at near-atomic resolution.

iSPA Workflow

To more effectively harness the power of cryo-EM in pharma, you need an industrialized single particle analysis (iSPA) workflow solution that delivers structural insights at the pace of your drug discovery process. The iSPA Workflow solution from Thermo Fisher Scientific was developed in partnership with users in the pharmaceutical industry. This complete and unique product solution provides a comprehensive cryo-EM workflow from sample vitrification to data collection, and is specifically designed to support the drug discovery process. 

The iSPA Workflow solution is optimized to offer:

  • Industry leading productivity with enhanced automation
  • Ease-of-use for structural biologists with minimal cryo-EM experience   
  • High reliability of instruments 

Krios Rx Cryo-TEM

Krios Rx Cryo-TEM

The flagship of the iSPA Workflow is the Thermo Scientific Krios Rx Cryo-TEM. This high-end fixed-voltage (300 kV) microscope is optimized for high-throughput single particle analysis, allowing you to generate de novo and repeat structures at the pace needed for drug discovery. It comes standard equipped with a Thermo Scientific Falcon 4 Direct Electron Detector, enhanced automation features, and a pharma-dedicated service package that guarantees an uptime of 90% and a throughput of over 400 high-quality images per hour with a Falcon 4 detector.*

Learn more ›

*Terms and conditions apply. 


Accelerate and Advance for pharma

Accelerate Rx & Advance Rx Service Packages

Accelerate Rx & Advance Rx are pharma-dedicated service packages that include productivity monitoring to maximize system utilization, a 90% up-time guarantee (with a Falcon 4 detector), and throughput validation of over 400 high-quality images per hour with your instrument.* This outcome-based service package also includes application training, remote applications support, workflow validation, a workflow application, and a customer dashboard with productivity and uptime reporting.

Learn more ›

*Terms and conditions apply. 


Remarkable results with the iSPA Workflow

"Receiving the data we need overnight, versus a week, allows us to solve several structures as opposed to one. Automated data collection means that we can schedule a full weekend run on six grids without having to manually change them, improving the time requested from sample to structure."

Dr. Giovanna Scapin, Chief Scientist at NanoImaging Services

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Learn how the iSPA Workflow solution can power structural insights that meet the pace of your drug discovery process.

Meet the Krios Rx Cryo-TEM, the flagship of the iSPA Workflow solution, optimized for single particle analysis in structure-based drug design.

Pharma collaborators share how the Krios Rx Cryo-TEM offers enhanced automation features for optimal data collection and ease of use.

Pharma collaborators share how the Falcon 4 Detector enables highest throughput imaging for a robust workflow, with optimized EER data format.

Hear how the Accelerate Rx and Advance Rx pharma-dedicated service packages offer comprehensive support to ensure industry leading productivity and instrument reliability.

Learn how the iSPA Workflow solution can power structural insights that meet the pace of your drug discovery process.

Meet the Krios Rx Cryo-TEM, the flagship of the iSPA Workflow solution, optimized for single particle analysis in structure-based drug design.

Pharma collaborators share how the Krios Rx Cryo-TEM offers enhanced automation features for optimal data collection and ease of use.

Pharma collaborators share how the Falcon 4 Detector enables highest throughput imaging for a robust workflow, with optimized EER data format.

Hear how the Accelerate Rx and Advance Rx pharma-dedicated service packages offer comprehensive support to ensure industry leading productivity and instrument reliability.

Applications

Drug discovery

Drug Discovery

Learn how to take advantage of rational drug design for many major drug target classes, leading to best-in-class drugs.


Products

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Krios Rx Cryo-TEM

  • Industry leading productivity and ease of use
  • Fixed 300 kV voltage for SPA only
  • Pharma-dedicated service package for guaranteed reliability

Vitrobot System

  • Fully automated sample vitrification
  • Blotting device
  • Semi-automated grid transfer
  • High sample throughput

EPU 2 Software

  • Microscope-embedded solution for single particle acquisition
  • Optimized for high-throughput particle collection
  • Compatible with film, CCD cameras, and direct electron detectors

Falcon 4i Detector

  • High throughput for more images per hour
  • Unsurpassed imaging quality with high DQE
  • Lossless data compression with EER

Glacios Cryo-TEM

  • Flexible Accelerating Voltage 80-200 kV
  • Industry-leading Autoloader for cryogenic sample manipulation
  • Small footprint
  • Enhanced ease-of-use

EM Services for Pharma

  • Maximize output with system uptime and throughput commitments
  • Drive improvement with enhanced visibility to system data
  • Comprehensive maintenance and applications support
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