CellInsight CX7 High-Content Screening (HCS) Platform
The Thermo Scientific CellInsight CX7 High-Content Screening (HCS) Platform is an integrated system for all-around performance in screening and analysis.
Flexible imaging options with the CellInsight CX7 High-Content Screening Platform
With the CellInsight CX7 High-Content Screening Platform you have a choice of imaging modes to extract the information you need from your samples. Use the entire fluorescence spectrum to optimize your assay, and select either widefield or confocal optics for any channel. You also have 4-color brightfield options for colorimetric analysis of tissue sections. You can’t always predict what assays are coming next, but the CellInsight CX7 HCS Platform has you covered.
CellInsight CX7 system highlights
|Illumination||7-channel solid-state LED light engine|
|Camera||Photometrics X1 camera|
|Widefield||7-channel fluorescent imaging|
|Brightfield||5-channel brightfield imaging|
|Confocal||7-channel confocal imaging|
|Objectives||3-position objective (range from 2x–40x, low and high NA)|
|Focus||Software and laser-based autofocus for consistent scan times|
|Automation||Configured for fully automated plate handling and scanning|
|Software||HCS Studio software for integrated data collection and analysis|
A549 cell image acquired using the Thermo Scientific™ CellInsight™ CX7 platform and stained with Invitrogen™ HCS CellMask™ Blue (blue), Invitrogen™ Alexa Fluor™ 488 Phalloidin (green), and Invitrogen™ Alexa Fluor™ 750 goat anti–mouse IgG secondary antibody (pink).
Three-color brightfield image of fixed human breast cancer tissue stained with KI67-DAB and counterstained with hematoxylin and eosin and imaged with the Thermo Scientific™ CellInsight™ CX7 platform.
Reagents optimized for high-content screening
Drawing on decades of experience in fluorescence imaging, Invitrogen™ Molecular Probes™ HCS products are developed using Thermo Scientific High-Content Platforms with special considerations for the high-throughput workflow and automated imaging:
- Cell and nuclear masks for automated demarcation
- Robust functional probes for cell health interrogation
- Flexible assay workflow for automated processing
- Broad fluorophore choice for easy multiplexing
- Validated on multiple imaging platforms
Other cell structure and segmentation tools
Clear identification of cell and nuclear boundaries in automated imaging requires fiducial markers that will label cellular structures robustly and reproducibly. Cell masks are designed specifically for automated imaging. Molecular Probes cell structure labels are widely used in microscope imaging and HCS.
Other cell health and cytotoxicity assays
We offer a diverse selection of imaging and microscopy assays for the analysis of cell viability, proliferation, apoptosis, cell cycle and DNA repair, migration, adhesion and other cellular functions. Many of these assays have been validated specifically for HCS platforms.
Browse cell health and cytotoxicity assays by application:
Microplates and slides
Compatible with SBS standard microplates (6–1,536 well) and slides
Orbitor RS Microplate Mover
Increase throughput, storage capacity and operational flexibility with the Thermo Scientific™ Orbitor™ RS Microplate Mover—industrial-sized performance within a compact, benchtop mover.
The Orbitor RS is a high-speed microplate mover offering proven, reliable performance with totally flexible plate handling. Extensive vertical reach allows multiple stacked or high density instruments to be loaded in a small footprint, and a bi-directional telescoping arm provides superior reach, improved user safety and unlimited base rotations within a 360° workspace.
|Camera||Photometrics X1 CCD:
|Data management||Compatible with Thermo Scientific™ Store™ Image and Database Management Software|
|Dimensions||20 in. x 32 in. x 18 in. (50.8 cm x 81.3 cm x 45.7 cm)|
|Image compatibility||JPG, BMP, GIF, PNG, TIF, C01, DIB|
|Light source||LED, solid-state 7-color light engine used with provided filter sets offers the following excitation/emission capabilities (Ex/Em, in nm):
|Objectives||Standard (Olympus™ objectives):
|PC||Windows 7 Professional 64-Bit PC with 32GB (4x8GB) RAM, Intel® Xeon® Processor 3.7GHz Turbo, RAID I Controller with 1.8TB Hard Drive and 256 Boot Drive.
Includes Dell 24" High Resolution Widescreen Monitor or equivalent, keyboard and mouse.
|Software||Thermo Scientific™ HCS Studio™ 3.0 Cell Analysis Software|
|Weight||150 lb (68 kg)|
- Elucidating the Mechanism of Cell Death Through the use of High-Content Analysis
- High-Content Cell Cycle Screening: Pairing FUCCI Technology with HCS Studio 2.0 Software and FCS Express Image Cytometry
- Monitoring Neurite Morphology and Synapse Formation in Primary Neurons for Neurotoxicity Assessments and Drug Screening
- Multiplexed Mitosis and Apoptosis Analysis
- Multiplexing with NIR
- Optimizing the High-Content Analysis of Cell Morphology Using Multi-Dimensional Imaging on the ArrayScan XTI HCA Reader – Part 1 Stem Cell Colonies
- Oxidative Stress Measurements Made Easy: CellROX Reagents with Simple Workflow for High-Content Imaging
- Using a High-Content Analysis Database as a Repository for Data
For Research Use Only. Not for use in diagnostic procedures.