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Invitrogen
DR4 Monoclonal Antibody (DR-4-02), FITC
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FIGURE: 1 / 1
DR4 Antibody (A15746) in Flow
Oncology letters 2021 -
Figure 4. Effects of TRAIL-Mu3 on the expression levels and distribution of DRs. (A) TRAIL-Mu3 upregulated DR4 and DR5 expression in PANC-1 cells. *P<0.001 vs. TRAIL. (B) TRAIL-Mu3 and TRAIL had no effect on the distribution of DR4 in lipid rafts, while (C) TRAIL-Mu3 promoted DR5 clustering into lipid rafts. Lipid rafts were stained with FITC-conjugated rabbit anti-Ctx (green) and DR4/DR5 was counterstained... View More
Product Details
A15746
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
DR-4-02
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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