FPRL1, a Chemoattractant Receptor also called Lipoxin A4 Receptor, functions as a component of the inflammatory response. Its stimulation results in neutrophil activation and desensitization of chemokine receptors in monocytes (Le et al., 2000). The receptor is up-regulated by interleukin-1 in normal human synovial fibroblasts. The immunodeficiency virus type 1 (HIV-1) envelope protein gp41 can activate the innate host immune cells through FPRL1 and induces directional migration and calcium mobilization in human monocytes and neutrophils. Recently, FPRL1 has been implicated in Alzheimers Disease. FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries. Caution: Formyl peptide receptor-like receptor 1 (FPRL1) and Formyl peptide receptor 2 (FPR2) are the same, and FPR2 is distinct from FPRL2.
ALXR; FMLP-R-I; FMLP-related receptor I; FMLPX; Formyl peptide receptor-like 1; FPR-like 1; Fpr-rs1; FPR2; FPR2A; FPRH1; FPRH2; Fprl-1; FPRL1; HM63; Lipoxin A4 receptor; lipoxin A4 receptor (formyl peptide receptor related); Lipoxin receptor; LXA4 receptor; LXA4R; N-formyl peptide receptor 2; RFP