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Invitrogen
FPR2 Polyclonal Antibody
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FIGURE: 1 / 2
FPR2 Antibody (720293) in WB
Western blot analysis was performed on membrane enriched cell extracts (30 µg lysate) of THP-1 (Lane 1), K-562 (Lane 2), HeLa (Lane 3) and tissue extracts of Mouse stomach (Lane 4), Rat Brain (Lane 5) and Mouse Brain (Lane 6). The blots were probed with Formyl peptide receptor 2/FPR2 Rabbit Polyclonal antibody (Product # 720293, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A ~ 41 kDa band corresponding to ... View More
Product Details
720293
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human FPR2 (aa 9-26)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Dog, Rabbit and Pig.
Target Information
Formyl peptide receptor 2 (FPR2) is a low affinity receptor for N-formyl-methionyl peptides. Binding of FMLP to FPR2 causes activation of neutrophils. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ALX; FMLP-R-I; FMLP-related receptor I; fMLPR1; Formyl peptide receptor 2; formyl peptide receptor, related sequence 2; formyl peptide receptor, related sequence 2-like; Formyl peptide receptor-like 1; Formylpeptide receptor-related sequence 2; FPR-like 1; Fpr-rs1; Fprl-1; HM63; Lipoxin A4 receptor; lipoxin A4 receptor (formyl peptide receptor related); Lipoxin A4 receptor-like protein; Lipoxin receptor; LXA4 receptor; N-formyl peptide receptor 2; N-formylpeptide receptor-like 2; RFP; unnamed protein product
Gene Aliases: ALX; ALXR; E330010I07Rik; FMLP-R-II; FMLPX; Fpr-rs2; FPR2; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
UniProt ID: (Human) P25090, (Mouse) O88536
Entrez Gene ID: (Human) 2358, (Mouse) 14289, (Rat) 690158
beta-amyloid binding
complement receptor activity
G-protein coupled receptor activity
N-formyl peptide receptor activity
scavenger receptor binding
protein binding
signaling receptor activity
cargo receptor activity
RAGE receptor binding
signal transducer activity
receptor activity
G-protein coupled receptor
microglial cell activation
complement receptor mediated signaling pathway
immune response-regulating cell surface receptor signaling pathway
receptor-mediated endocytosis
chemotaxis
inflammatory response
cell communication
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
signaling
positive regulation of superoxide anion generation
defense response to bacterium
negative regulation of neuron apoptotic process
positive regulation of innate immune response
astrocyte activation
negative regulation of inflammatory response
positive regulation of phagocytosis
positive chemotaxis
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
dentinogenesis
cellular response to beta-amyloid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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