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7TM Antibodies
FPR2, Formylpeptide Receptor 2 Polyclonal Antibody
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FIGURE: 1 / 2
FPR2, Formylpeptide Receptor 2 Antibody (7TM0223N) in IHC (P)
Immunohistochemical identification of the Formylpeptide Receptor 2 in striatum. Sections were dewaxed, microwaved in citric acid, and incubated with anti-FPR2 (Formylpeptide Receptor 2) antibody (7TM0223N) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Color was developed by incubation in 3-amino-9-ethylcarbazole (AEC), and secti... View More
Product Details
7TM0223N
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide presents part of carboxyl-terminal tail of human FPR2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Formyl peptide receptor 2 (FPR2) is a low affinity receptor for N-formyl-methionyl peptides. Binding of FMLP to FPR2 causes activation of neutrophils. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALX; FMLP-R-I; FMLP-related receptor I; fMLPR1; Formyl peptide receptor-like 1; FPR-like 1; Fpr-rs1; Fprl-1; HM63; Lipoxin A4 receptor; lipoxin A4 receptor (formyl peptide receptor related); Lipoxin receptor; LXA4 receptor; N-formyl peptide receptor 2; RFP; unnamed protein product
Gene Aliases: ALX; ALXR; FMLP-R-II; FMLPX; FPR2; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
UniProt ID: (Human) P25090
Entrez Gene ID: (Human) 2358
microglial cell activation
complement receptor mediated signaling pathway
immune response-regulating cell surface receptor signaling pathway
receptor-mediated endocytosis
chemotaxis
inflammatory response
cell communication
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
signaling
positive regulation of superoxide anion generation
defense response to bacterium
negative regulation of neuron apoptotic process
positive regulation of innate immune response
astrocyte activation
negative regulation of inflammatory response
positive regulation of phagocytosis
positive chemotaxis
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
dentinogenesis
cellular response to beta-amyloid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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