The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence.
Adult folate-binding protein; FBP; folate binding protein; folate binding protein 1; Folate receptor 1; Folate receptor 1 (adult); Folate receptor alpha; Folate receptor, adult; Folate-binding protein 1; FOLR; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18