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Folate Receptor alpha Polyclonal Antibody
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FIGURE: 1 / 6
Folate Receptor alpha Antibody (PA5-101588) in IHC (P)
Immunohistochemistry analysis of Folate Receptor alpha in human pancreatic cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Folate Receptor alpha polyclonal antibody (Product # PA5-101588) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antib... View More
Product Details
PA5-101588
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FOLR1(Accession P15328), corresponding to amino acid residues G48-R98.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FOLR1.
Target Information
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adult folate-binding protein; FBP; folate binding protein; folate binding protein 1; Folate receptor 1; folate receptor 1 (adult); Folate receptor alpha; Folate receptor, adult; Folate-binding protein 1; folate-binding protein precursor; FOLR1; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18
Gene Aliases: FBP; FBP1; Folbp-1; Folbp1; FOLR; FOLR1; FRalpha; NCFTD
UniProt ID: (Human) P15328, (Mouse) P35846
Entrez Gene ID: (Human) 2348, (Rat) 171049, (Mouse) 14275
folic acid transport
folic acid metabolic process
heart looping
neural crest cell migration involved in heart formation
cardiac neural crest cell migration involved in outflow tract morphogenesis
receptor-mediated endocytosis
cell adhesion
fusion of sperm to egg plasma membrane
regulation of transforming growth factor beta receptor signaling pathway
axon regeneration
sperm-egg recognition
tetrahydrofolate biosynthetic process
response to axon injury
regulation of canonical Wnt signaling pathway
pharyngeal arch artery morphogenesis
anterior neural tube closure
cellular response to folic acid
posttranslational protein targeting to membrane
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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