NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.
CD161 antigen-like family member C; CD161c; killer cell lectin-like receptor subfamily A member 1C; Killer cell lectin-like receptor subfamily B member 1C; Klrb1d; Ly-55c; Ly55b; Ly55d; lymphocyte antigen 55 complex, locus C; Lymphocyte antigen 55c; lymphocyte antigen 59; MGC163757; MGC163759; natural killer cell receptor protein NKR-P1C; natural killer cell receptor-P1; Natural killer cell surface protein P1-40; natural killer cell-associated antigen 1; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1B; NKR-P1C; Nkrp1-b; Nkrp1d