NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.
CARD15; caspase recruitment domain family, member 15; Caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; IBD1; Inflammatory Bowel disease protein 1; NOD 2; NOD-2; nucleotide-binding oligomerization domain-containing protein 2
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