Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
C15orf42; SLD3; TICRR; TOPBP1-interacting checkpoint and replication regulator; topBP1-interacting replication-stimulating protein; TopBP1-interacting, replication-stimulating protein; Treslin