|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||19 amino acid peptide near the carboxy terminus of human TICRR|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||20 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
A recommended positive control is human small intestine tissue lysate.
At least two isoforms of TICRR are known to exist.
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
C15orf42; SLD3; TICRR; TOPBP1-interacting checkpoint and replication regulator; topBP1-interacting replication-stimulating protein; topBP1-interacting, replication-stimulating protein
C15orf42; SLD3; TICRR; Treslin