AMIGO3 Antibodies

Target Information

Amphoterin induced gene and ORF 3 (AMIGO3) is a gene located on chromosome 3p21.31, encoding a member of the AMIGO family of proteins involved in cell adhesion, axon guidance, and neuronal signaling. AMIGO3 is primarily expressed in the central nervous system, playing a crucial role in neural development and the maintenance of neural circuits. Functionally, AMIGO3 contributes to neuronal growth and synapse formation, impacting processes such as neural plasticity and signal transduction. The protein's activity facilitates interactions with other neuronal surface proteins, influencing axon pathfinding and connectivity. Aberrant expression or mutations in AMIGO3 have been linked to neurological disorders and neurodegenerative diseases, suggesting its significance in neural health and pathology. Research into AMIGO3 continues to explore its potential therapeutic applications in promoting neural repair and modulating synaptic functions, offering insights into strategies for addressing nervous system disorders.

Synonyms

adhesion molecule with Ig like domain 3; adhesion molecule with Ig-like domain 3; ALI3; alivin 3; alivin-3; AMIGO3; AMIGO-3; amigo3 {ECO:0000312; amphoterin induced gene and ORF 3; amphoterin-induced gene and ORF 3; amphoterin-induced protein 3; E430002N15Rik; EMBL:AAO48952.1, ECO:0000312; Kiaa1851; MGC120552; mKIAA1851; RGD:631413}; transmembrane protein AMIGO3; UNQ6084/PRO20089