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Proteintech
KIR3DL1 Polyclonal Antibody
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Product Details
13335-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KIR3DL1 Fusion Protein Ag4152 (22-344 aa encoded by BC028206)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is raised against 22-344 amino acids of human KIR3DL1 and recognizes both KIR3DL1 (49 kDa) and KIR3DS1 (43 kDa).
Immunogen sequence: HMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML YKEDRIHVPI FHGRIFQEGF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPMVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIG (22-344 aa encoded by BC028206)
Target Information
KIR3DL1 are Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. 4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3DL1; AMB11; CD158 antigen-like family member E; CD158e; CD158e antigen; CD158E1/2; CD158E2; CL11; CL2; HLA-BW4-specific inhibitory NK cell receptor; Killer cell immunoglobulin-like receptor 3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; KIR antigen 3DL1; KIR G1; KIR3D; KIR3DL1; KIR3DS1; MGC119726; MGC119728; MGC126589; MGC126591; natural killer cell receptor; Natural killer-associated transcript 3; NK receptor; NKAT-3; NKAT10; nkat3-delta-Ig1; putative; p70; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK; p70 NK receptor CL-2/CL-11
Gene Aliases: CD158E; CD158E1; KIR; KIR2DL5B; KIR3DL1; KIR3DL1/S1; NKAT-3; NKAT3; NKB1; NKB1B
UniProt ID: (Human) P43629
Entrez Gene ID: (Human) 3811
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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