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Proteintech
SCF Polyclonal Antibody
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Product Details
26582-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SCF Fusion Protein Ag25075 (28-214 aa encoded by BC074725)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ICRNRVTNN VKDVTKLVAN LPKDYMITLK YVPGMDVLPS HCWISEMVVQ LSDSLTDLLD KFSNISEGLS NYSIIDKLVN IVDDLVECVK ENSSKDLKKS FKSPEPRLFT PEEFFRIFNR SIDAFKDFVV ASETSDCVVS STLSPEKDSR VSVTKPFMLP PVAASSLRND SSSSNRKAKN PPGDSSLH (28-214 aa encoded by BC074725 )
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-kit ligand; cloud gray; DKFZp686F2250; familial progressive hyperpigmentation 2; grizzle-belly; growth factor; H-SCF; Hematopoietic growth factor KL; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; polypeptide growth factor; SCF; SCF220; SCF248; Steel factor; steel factor/kit ligand; Stem cell factor; stem cell factor KL-1; unnamed protein product
Gene Aliases: blz; Clo; Con; contrasted; DCUA; DFNA69; FPH2; FPHH; Gb; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7; Sl; SLF; WS2F
UniProt ID: (Human) P21583, (Mouse) P20826, (Rat) P21581
Entrez Gene ID: (Human) 4254, (Mouse) 17311, (Rat) 60427
ovarian follicle development
neural crest cell migration
positive regulation of leukocyte migration
positive regulation of myeloid leukocyte differentiation
cell adhesion
germ cell development
positive regulation of cell proliferation
negative regulation of mast cell apoptotic process
embryonic hemopoiesis
ectopic germ cell programmed cell death
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of melanocyte differentiation
positive regulation of DNA replication
positive regulation of Ras protein signal transduction
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of mast cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
hematopoietic progenitor cell differentiation
myeloid leukocyte differentiation
developmental process involved in reproduction
apoptotic process
Ras protein signal transduction
cell proliferation
male gonad development
mast cell apoptotic process
T cell proliferation
positive regulation of T cell proliferation
animal organ development
mast cell proliferation
melanocyte migration
mast cell migration
positive regulation of hematopoietic progenitor cell differentiation
positive regulation of hematopoietic stem cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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