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NeoBiotechnologies

FOXA1/HNF3A Monoclonal Antibody (FOXA1/1241)

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FOXA1/HNF3A Monoclonal Antibody (FOXA1/1241)

Product Details

3169-MSM1-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

FOXA1/1241

Immunogen

Recombinant human FOXA1 protein fragment (aa372-472).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

20 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ci-fkh; fkd7; fkh; Forkhead box protein A1; forkhead-7; FoxA4a; hepatocyte nuclear factor 3, alpha; Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; HNF3-alpha; HNF3alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF-3A; tFoxA1; Transcription factor 3A; unnamed protein product; xfkh1; xfkh2

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Gene Aliases: FOXA1; HNF3A; Tcf-3a; TCF3A

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UniProt ID: (Human) P55317, (Rat) P23512

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Entrez Gene ID: (Human) 3169, (Rat) 25098

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding double-stranded DNA binding transcription factor binding transcription regulatory region DNA binding winged helix/forkhead transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway smoothened signaling pathway anatomical structure morphogenesis regulation of gene expression negative regulation of epithelial to mesenchymal transition dorsal/ventral neural tube patterning cell differentiation neuron differentiation lung development response to estradiol positive regulation of intracellular estrogen receptor signaling pathway tube morphogenesis hormone metabolic process glucose homeostasis positive regulation of apoptotic process positive regulation of smoothened signaling pathway positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis neuron fate specification positive regulation of sequence-specific DNA binding transcription factor activity regulation of cell cycle lung morphogenesis epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development mesenchymal-epithelial cell signaling involved in prostate gland development prostate gland epithelium morphogenesis prostate gland stromal morphogenesis epithelial cell maturation involved in prostate gland development alveolar secondary septum development connective tissue development dopaminergic neuron differentiation respiratory basal cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of dopaminergic neuron differentiation positive regulation of cell-cell adhesion mediated by cadherin transcription, DNA-templated multicellular organism development chromatin modification positive regulation of neuron differentiation epithelial-mesenchymal signaling involved in prostate gland development
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