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Active Motif
MMSET / WHSC1 Monoclonal Antibody (29D1)
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Product Details
39879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
29D1
Immunogen
This MMSET / WHSC1 antibody was raised against a recombinant protein corresponding to amino acids 1-647 of human MMSET-I.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
70mM tris, pH 8, with 105mM NaCl, 0.07mM EDTA, 31mM glycine, 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: contains SET domain; histone methyltransferase; MMSET type III; Histone-lysine N-methyltransferase NSD2; IL5 promoter REII region-binding protein; MMSET; multiple myeloma SET domain containing protein type III; Multiple myeloma SET domain-containing protein; Nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; Protein trithorax-5; trithorax/ash1-related protein 5; unnamed protein product; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1 protein
Gene Aliases: KIAA1090; KMT3F; KMT3G; MMSET; NSD2; RAUST; REIIBP; TRX5; WHS; WHSC1
UniProt ID: (Human) O96028
Entrez Gene ID: (Human) 7468
DNA binding
chromatin binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity
histone methyltransferase activity (H4-K20 specific)
sequence-specific DNA binding
metal ion binding
histone methyltransferase activity (H3-K36 specific)
histone H3 methyltransferase activity
histone H3K36 dimethyltransferase activity
histone H3K36 trimethyltransferase activity
negative regulation of transcription from RNA polymerase II promoter
membranous septum morphogenesis
atrial septum primum morphogenesis
atrial septum secundum morphogenesis
double-strand break repair
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
methylation
positive regulation of isotype switching to IgA isotypes
bone development
regulation of establishment of protein localization
regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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