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Proteintech

RACK1/GNB2L1 Monoclonal Antibody (1E11A7)

View all (22) RACK1 antibodies

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Product Details

66940-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:20,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunocytochemistry (ICC/IF)

1:400
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1E11A7

Immunogen

RACK1; GNB2L1 Fusion Protein Ag26708

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Amount

150 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12-3; activated protein kinase C receptor; Cell proliferation-inducing gene 21 protein; G-beta like protein; GNB2L1; guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide binding protein related; guanine nucleotide binding protein, beta 2, related sequence 1; guanine nucleotide binding protein, beta polypeptide 2-like 1; guanine nucleotide binding protein, beta-2, related sequence 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; p205; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; protein kinase C receptor; rack-1; Receptor for activated C kinase; Receptor for activated C kinase 1; receptor for activated protein kinase C; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1; unnamed protein product

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Gene Aliases: AL033335; GB-like; Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; p205; PIG21; RACK1

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UniProt ID: (Rat) P63245, (Mouse) P68040, (Pig) P63246, (Human) P63244

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Entrez Gene ID: (Rat) 83427, (Mouse) 14694, (Pig) 397605, (Human) 10399

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Function(s)
protein kinase C binding ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein phosphatase binding protein tyrosine kinase inhibitor activity receptor tyrosine kinase binding SH2 domain binding protein homodimerization activity poly(A) RNA binding receptor activity protein binding signaling adaptor activity cyclin binding ribosome binding BH3 domain binding RNA binding receptor binding enzyme activator activity protein serine/threonine kinase inhibitor activity identical protein binding translation regulator activity cadherin binding binding, bridging
Process(es)
positive regulation of protein phosphorylation apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process cell cycle gastrulation negative regulation of gene expression protein ubiquitination negative regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of cell migration positive regulation of protein complex assembly negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization negative regulation of peptidyl-serine phosphorylation positive regulation of Golgi to plasma membrane protein transport positive regulation of apoptotic process pigmentation positive regulation of GTPase activity rhythmic process negative regulation of phagocytosis regulation of cell division positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization negative regulation of protein tyrosine kinase activity cellular response to glucose stimulus cellular response to growth factor stimulus rescue of stalled ribosome negative regulation of hydrogen peroxide-induced neuron death regulation of establishment of cell polarity positive regulation of gastrulation positive regulation of intrinsic apoptotic signaling pathway osteoblast differentiation protein kinase C-activating G-protein coupled receptor signaling pathway negative regulation of translation positive regulation of cAMP catabolic process positive regulation of protein homooligomerization regulation of establishment of protein localization to plasma membrane regulation of translation multicellular organism development protein localization intracellular signal transduction regulation of growth cytoplasmic translation translation negative regulation of smoothened signaling pathway regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of endoplasmic reticulum unfolded protein response negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide negative regulation of translational frameshifting
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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