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RACK1, GNB2L1 Monoclonal Antibody (1E11A7), CoraLite® 594

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RACK1, GNB2L1 Monoclonal Antibody (1E11A7), CoraLite® 594

Product Details

CL59466940100UL

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1E11A7

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

RACK1 (receptor for activated C kinase 1) was identified through its binding to various PKC isoforms. Its main function is to recruit PKC and various other proteins to specific locations to form multiprotein complexes, mediating various signal pathways. RACK1 is required for VANGL2 membrane localization and for PTK2/FAK1 phosphorylation and dephosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cell proliferation-inducing gene 21 protein; GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein beta polypeptide 2-like 1; Guanine nucleotide-binding protein subunit beta-2-like 1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; HLC-7; Human lung cancer oncogene 7 protein; lung cancer oncogene 7; OTTHUMP00000223870; OTTHUMP00000223891; OTTHUMP00000223893; OTTHUMP00000223900; OTTHUMP00000223901; OTTHUMP00000223902; OTTHUMP00000223930; OTTHUMP00000223931; PIG21; proliferation-inducing gene 21; protein homologous to chicken B complex protein, guanine nucleotide binding; rack-1; Receptor for activated C kinase; Receptor for activated C kinase 1; Receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; Small ribosomal subunit protein RACK1; unnamed protein product

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Gene Aliases: Gnb2-rs1; GNB2L1; H12.3; HLC-7; HLC7; PIG21; RACK1

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UniProt ID: (Human) P63244

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Entrez Gene ID: (Human) 10399

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Function(s)
RNA binding protein kinase C binding receptor binding protein binding enzyme activator activity ion channel inhibitor activity cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein phosphatase binding protein serine/threonine kinase inhibitor activity protein tyrosine kinase inhibitor activity cyclin binding receptor tyrosine kinase binding signaling adaptor activity SH2 domain binding identical protein binding protein homodimerization activity ribosome binding translation regulator activity cadherin binding BH3 domain binding binding, bridging
Process(es)
positive regulation of protein phosphorylation cytoplasmic translation translation regulation of translation apoptotic process gastrulation negative regulation of gene expression protein ubiquitination negative regulation of translation negative regulation of Wnt signaling pathway negative regulation of cell growth positive regulation of cell migration positive regulation of protein complex assembly negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization positive regulation of Golgi to plasma membrane protein transport positive regulation of apoptotic process pigmentation positive regulation of GTPase activity negative regulation of smoothened signaling pathway rhythmic process negative regulation of phagocytosis regulation of cell division regulation of cell cycle negative regulation of protein kinase B signaling positive regulation of mitochondrial depolarization cellular response to glucose stimulus cellular response to growth factor stimulus rescue of stalled ribosome regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of endoplasmic reticulum unfolded protein response negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide regulation of establishment of cell polarity positive regulation of gastrulation negative regulation of translational frameshifting positive regulation of intrinsic apoptotic signaling pathway
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