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Invitrogen

Annexin A1 Recombinant Rabbit Monoclonal Antibody (7H46L26)

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Annexin A1 Recombinant Rabbit Monoclonal Antibody (7H46L26)

Product Details

702057

Applications
Tested Dilution
Publications

Western Blot (WB)

2 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

7H46L26

Immunogen

Protein corresponding to Human ANXA1 (aa 33-346)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633055

Product Specific Information

This antibody is predicted to react with Monkey, Dog and Rabbit

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ANAX1; Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; ANX1; ANXA1; Calpactin II; Calpactin-2; Chromobindin-9; epididymis secretory sperm binding protein; lipocortin 1; Lipocortin I; LPC1; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1; unnamed protein product

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Gene Aliases: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1

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UniProt ID: (Human) P04083, (Mouse) P10107

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Entrez Gene ID: (Human) 301, (Mouse) 16952

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Function(s)
phosphatidylserine binding phospholipase inhibitor activity receptor binding calcium ion binding protein binding phospholipid binding calcium-dependent phospholipid binding lipid binding phospholipase A2 inhibitor activity metal ion binding calcium-dependent protein binding cadherin binding involved in cell-cell adhesion single-stranded DNA binding single-stranded RNA binding helicase activity structural molecule activity protein binding, bridging double-stranded DNA-dependent ATPase activity annealing helicase activity protein homodimerization activity calcium-binding protein
Process(es)
neutrophil homeostasis adaptive immune response immune system process monocyte chemotaxis regulation of leukocyte migration phagocytosis inflammatory response signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger regulation of cell shape myoblast migration involved in skeletal muscle regeneration peptide cross-linking actin cytoskeleton organization keratinocyte differentiation positive regulation of vesicle fusion regulation of interleukin-1 production negative regulation of interleukin-8 production positive regulation of interleukin-2 production positive regulation of neutrophil apoptotic process cellular response to vascular endothelial growth factor stimulus positive regulation of T cell proliferation neutrophil activation regulation of cell proliferation negative regulation of apoptotic process innate immune response positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation negative regulation of exocytosis alpha-beta T cell differentiation regulation of hormone secretion arachidonic acid secretion regulation of inflammatory response negative regulation of transport positive regulation of multicellular organismal process cellular response to glucocorticoid stimulus granulocyte chemotaxis positive regulation of cell migration involved in sprouting angiogenesis positive regulation of wound healing neutrophil clearance cell-cell adhesion positive regulation of G1/S transition of mitotic cell cycle DNA strand renaturation insulin secretion positive regulation of prostaglandin biosynthetic process DNA duplex unwinding DNA rewinding positive regulation of apoptotic process negative regulation of protein secretion cellular response to hydrogen peroxide prolactin secretion negative regulation of phospholipase A2 activity negative regulation of interleukin-8 secretion
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