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Antibodies Inc
Ataxin-1/11NQ Monoclonal Antibody (N76/8), FL490
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Product Details
75-117-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N76/8
Immunogen
Synthetic peptide amino acids 164-197 of mouse ataxin-1 (accession number P54254).
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: ATTPSQRSQL EAYSTLLANM GSLSQAPGHK VEPP
Target Information
Ataxin-1 (11NQ) refers to a specific isoform or variant of the Ataxin-1 protein, characterized by having 11 normal glutamine (Q) residues in its polyglutamine (polyQ) tract. This is in contrast to the expanded polyQ tracts found in disease-causing variants associated with spinocerebellar ataxia type 1 (SCA1). Ataxin-1 (11NQ) serves as a model for studying the normal physiological roles of Ataxin-1 and provides a contrast to the pathogenic forms associated with neurodegenerative diseases, enhancing our understanding of protein misfolding and aggregation disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alt-ATXN1; alternative ataxin1; Ataxin-1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; Spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
Gene Aliases: 2900016G23Rik; ATX1; ATXN1; C85907; D6S504E; ENSMUSG00000074917; Gm10786; SCA1
UniProt ID: (Human) P54253, (Mouse) P54254, (Rat) Q63540
Entrez Gene ID: (Human) 6310, (Mouse) 20238, (Rat) 25049
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
adult locomotory behavior
visual learning
negative regulation of phosphorylation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
nuclear export
excitatory postsynaptic potential
positive regulation of glial cell proliferation
biological_process
transcription from RNA polymerase II promoter
RNA processing
brain development
learning
memory
social behavior
insulin-like growth factor receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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