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Ankyrin-B Monoclonal Antibody (N105/17)
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FIGURE: 1 / 4
Ankyrin-B Antibody (75-145) in IHC (F)
Nerve-muscle preparations from Glial or hCAST × Glial mice were treated acutely ex vivo with anti-GM1 Ab alone (Control) or with a source of complement (Injury) in the presence or absence of exogenous calpain inhibitor AK295. Representative images demonstrate nodal protein localization coinciding with complement deposition (green). AnkyrinB (AnkB) immunostaining (Product # 75-145, 1:300; magenta) was reduce... View More
Product Details
75-145
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N105/17
Immunogen
Fusion protein amino acids 203-496 of human Ankyrin-B (accession number Q01484) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-2; ank2; ankyrin 2, brain; ankyrin 2, neuronal; ankyrin 3, epithelial; ankyrin B; ankyrin, brain; Ankyrin-2; ankyrin-2, nonerythrocytic; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin; unnamed protein product
Gene Aliases: AI835472; ANK-2; ANK2; Ank3; ANKB; AW491075; brank-2; CFAP87; FAP87; LQT4
UniProt ID: (Human) Q01484, (Mouse) Q8C8R3
Entrez Gene ID: (Human) 287, (Mouse) 109676, (Rat) 362036
structural constituent of cytoskeleton
protein binding
cytoskeletal adaptor activity
enzyme binding
protein kinase binding
spectrin binding
protein binding, bridging
ion channel binding
ATPase binding
channel activator activity
potassium channel activator activity
phosphorylation-dependent protein binding
potassium channel regulator activity
membrane traffic protein
scaffold/adaptor protein
regulation of heart rate
atrial septum development
cellular calcium ion homeostasis
endocytosis
cytoskeleton organization
signal transduction
nervous system development
protein localization
positive regulation of gene expression
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
protein transport
paranodal junction assembly
regulation of protein stability
T-tubule organization
protein localization to cell surface
protein localization to M-band
protein localization to T-tubule
protein stabilization
regulation of release of sequestered calcium ion into cytosol
response to methylmercury
regulation of calcium ion transport
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
sarcoplasmic reticulum calcium ion transport
protein localization to endoplasmic reticulum
protein localization to plasma membrane
regulation of cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
atrial cardiac muscle cell action potential
SA node cell action potential
membrane depolarization during SA node cell action potential
atrial cardiac muscle cell to AV node cell communication
SA node cell to atrial cardiac muscle cell communication
regulation of heart rate by cardiac conduction
regulation of SA node cell action potential
regulation of atrial cardiac muscle cell action potential
positive regulation of potassium ion import
cellular protein localization
regulation of apoptotic process
positive regulation of potassium ion transport
cardiac muscle contraction
protein targeting to plasma membrane
regulation of cardiac muscle cell membrane potential
regulation of AV node cell action potential
positive regulation of potassium ion transmembrane transporter activity
regulation of calcium ion transmembrane transporter activity
positive regulation of calcium ion transmembrane transporter activity
regulation of cation channel activity
positive regulation of cation channel activity
protein localization to organelle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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