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Antibodies Inc
Kir6.2 Potassium Channel Monoclonal Antibody (N363/71)
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Product Details
75-393
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N363/71
Immunogen
Fusion protein amino acids 345-390 of rat Kir6.2 (accession number P70673) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: TARQLDEDRS LLDALTLASS RGPLRKRSVA VAKAKPKFSI SPDSLS
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; BIR; Inward rectifier K(+) channel Kir6.2; IRK11; KATP; KATP channel; MGC133230; Potassium channel, inwardly rectifying subfamily J member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11
Gene Aliases: Kcnj11; Kir6.2; mBIR
UniProt ID: (Rat) P70673, (Mouse) Q61743
Entrez Gene ID: (Rat) 83535, (Mouse) 16514
voltage-gated potassium channel activity
protein binding
ATP binding
protein C-terminus binding
ATP-activated inward rectifier potassium channel activity
G-protein activated inward rectifier potassium channel activity
ankyrin binding
heat shock protein binding
ion channel binding
inward rectifier potassium channel activity
voltage-gated ion channel activity
potassium ion binding
ion channel
transporter
response to ischemia
glucose metabolic process
potassium ion transport
potassium ion import
response to estradiol
response to ATP
response to testosterone
regulation of ion transmembrane transport
regulation of membrane potential
response to drug
negative regulation of insulin secretion
regulation of insulin secretion
neurological system process
cellular response to nicotine
cellular response to glucose stimulus
cellular response to tumor necrosis factor
potassium ion transmembrane transport
positive regulation of cation channel activity
transport
ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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