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NeoBiotechnologies
CD40 Ligand/CD154/TRAP1 (Activation Marker of T-Lymphocytes) Monoclonal Antibody (CD40LG, 2761)
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FIGURE: 1 / 7
CD40 Ligand/CD154/TRAP1 (Activation Marker of T-Lymphocytes) Antibody (959-MSM1-P1) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of paraformaldehyde-fixed Jurkat cells using CD40 Ligand, CD154, TRAP1 (Activation Marker of T-Lymphocytes) Monoclonal Antibody (Product # 959-MSM1-P1) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot..
Product Details
959-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
CD40LG, 2761
Immunogen
Recombinant fragment (around aa 108-261) of human CD40LG protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD154; CD40 antigen ligand; CD40 ligand; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member 5; unnamed protein product
Gene Aliases: CD154; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP
UniProt ID: (Human) P29965
Entrez Gene ID: (Human) 959
regulation of immunoglobulin production
regulation of immune system process
inflammatory response
immune response
cell communication
leukocyte cell-cell adhesion
cell surface receptor signaling pathway
integrin-mediated signaling pathway
regulation of gene expression
CD40 signaling pathway
signaling
platelet activation
B cell differentiation
T cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
B cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
isotype switching
positive regulation of NF-kappaB transcription factor activity
positive regulation of endothelial cell apoptotic process
positive regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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