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Bethyl Laboratories

TRAF2 Polyclonal Antibody

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TRAF2 Polyclonal Antibody

Product Details

A303-460A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 175 and 225 of Human TNF receptor-associated factor 2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.20 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adapter protein; E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3; unnamed protein product

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Gene Aliases: MGC:45012; RNF117; TRAF2; TRAP; TRAP3

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UniProt ID: (Human) Q12933

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Entrez Gene ID: (Human) 7186

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Function(s)
ubiquitin-protein transferase activity tumor necrosis factor receptor binding CD40 receptor binding protein binding zinc ion binding lipid binding transferase activity enzyme binding protein kinase binding protein phosphatase binding protein binding, bridging mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding thioesterase binding tumor necrosis factor receptor superfamily binding signaling adaptor activity identical protein binding tumor necrosis factor binding macromolecular complex binding sphingolipid binding metal ion binding ubiquitin protein ligase activity
Process(es)
regulation of immunoglobulin production regulation of production of molecular mediator of immune response positive regulation of T cell cytokine production apoptotic process signal transduction positive regulation of gene expression programmed cell death protein ubiquitination signal transduction involved in regulation of gene expression CD40 signaling pathway protein catabolic process positive regulation of interleukin-2 production tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process response to endoplasmic reticulum stress NIK/NF-kappaB signaling TORC1 signaling TORC2 signaling T cell activation regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly regulation of MAPK cascade positive regulation of JUN kinase activity innate immune response regulation of JNK cascade mRNA stabilization positive regulation of NF-kappaB transcription factor activity protein autoubiquitination protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein K63-linked ubiquitination cellular response to nitric oxide programmed necrotic cell death interleukin-17-mediated signaling pathway CD27 signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway TORC1 complex assembly TORC2 complex disassembly positive regulation of extrinsic apoptotic signaling pathway
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