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Invitrogen
alpha Synuclein Monoclonal Antibody (Syn 211)
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FIGURE: 1 / 30
alpha Synuclein Antibody (AHB0261) in ICC/IF
Immunofluorescence analysis of Synuclein-alpha was done on 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Synuclein-alpha Mouse Monoclonal Antibody (Product # AHB0261) at 1 µg/mL in 1% BSA and incubated for 3 hours at... View More
Product Details
AHB0261
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Avian,
C. elegans,
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
Syn 211
Immunogen
Recombinant human alpha-synuclein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.1% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for this product is SHSY-5Y cells. It will not cross-react with mouse or rat.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 41 synuclein; Alpha synuclein; Alpha-synuclein; I+/--synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; SNCA; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); unnamed protein product
Gene Aliases: NACP; PARK1; PARK4; PD1; SNCA
UniProt ID: (Human) P37840
Entrez Gene ID: (Human) 6622
SNARE binding
magnesium ion binding
transcription regulatory region sequence-specific DNA binding
actin binding
enzyme inhibitor activity
protein kinase inhibitor activity
cysteine-type endopeptidase inhibitor activity
fatty acid binding
copper ion binding
calcium ion binding
protein binding
phospholipid binding
microtubule binding
enzyme activator activity
ferrous iron binding
zinc ion binding
lipid binding
oxidoreductase activity
kinesin binding
enzyme binding
protein domain specific binding
Hsp70 protein binding
histone binding
identical protein binding
alpha-tubulin binding
phospholipase binding
metal ion binding
tau protein binding
beta-tubulin binding
phosphoprotein binding
binding, bridging
phospholipase D inhibitor activity
dynein complex binding
protein sequestering activity
transporter regulator activity
cuprous ion binding
negative regulation of transcription from RNA polymerase II promoter
microglial cell activation
positive regulation of receptor recycling
positive regulation of neurotransmitter secretion
synaptic transmission, dopaminergic
fatty acid metabolic process
neutral lipid metabolic process
phospholipid metabolic process
glutathione metabolic process
mitochondrial membrane organization
chemical synaptic transmission
neurotransmitter secretion
adult locomotory behavior
response to xenobiotic stimulus
response to iron(II) ion
negative regulation of platelet-derived growth factor receptor signaling pathway
regulation of glutamate secretion
regulation of dopamine secretion
synaptic vesicle exocytosis
synaptic vesicle priming
negative regulation of microtubule polymerization
receptor internalization
protein destabilization
response to magnesium ion
response to lipopolysaccharide
response to interferon-gamma
cellular response to oxidative stress
SNARE complex assembly
positive regulation of SNARE complex assembly
regulation of locomotion
response to cocaine
dopamine biosynthetic process
dopamine metabolic process
mitochondrial ATP synthesis coupled electron transport
regulation of macrophage activation
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of endocytosis
negative regulation of exocytosis
positive regulation of exocytosis
negative regulation of dopamine metabolic process
regulation of neurotransmitter secretion
behavioral response to cocaine
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
synaptic vesicle endocytosis
synaptic vesicle transport
positive regulation of inflammatory response
positive regulation of synaptic transmission
synapse organization
regulation of acyl-CoA biosynthetic process
protein oligomerization
protein tetramerization
positive regulation of release of sequestered calcium ion into cytosol
neuron apoptotic process
dopamine uptake involved in synaptic transmission
negative regulation of dopamine uptake involved in synaptic transmission
negative regulation of serotonin uptake
regulation of norepinephrine uptake
negative regulation of norepinephrine uptake
calcium ion homeostasis
excitatory postsynaptic potential
long-term synaptic potentiation
positive regulation of inositol phosphate biosynthetic process
membrane organization
negative regulation of thrombin receptor signaling pathway
regulation of microtubule cytoskeleton organization
response to interleukin-1
cellular response to copper ion
cellular response to epinephrine stimulus
fibril organization
negative regulation of mitochondrial electron transport, NADH to ubiquinone
positive regulation of hydrogen peroxide catabolic process
regulation of synaptic vesicle recycling
regulation of reactive oxygen species biosynthetic process
response to desipramine
positive regulation of protein localization to cell periphery
negative regulation of chaperone-mediated autophagy
regulation of presynapse assembly
amyloid fibril formation
regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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