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Invitrogen
ARPP19 Polyclonal Antibody
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Product Details
PA5-68127
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human ARPP19 (aa 6-25).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Human and Rat samples.
Target Information
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARPP-19; cAMP regulated phosphoprotein 19kDa; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein 19kDa; cAMP-regulated phosphoprotein ARPP-19; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; cyclic AMP phosphoprotein, 19 kDa; cyclic AMP phosphoprotein, 19kD
Gene Aliases: 19kDa; 2700024H10Rik; ARPP-16; ARPP-19; Arpp12; ARPP16; ARPP19; AW559096; ENSAL
UniProt ID: (Human) P56211, (Mouse) P56212, (Rat) Q712U5
Entrez Gene ID: (Human) 10776, (Mouse) 59046, (Rat) 60336
G2/M transition of mitotic cell cycle
cell cycle
mitotic nuclear division
positive regulation of gluconeogenesis
positive regulation of Ras protein signal transduction
cell division
dopamine receptor signaling pathway
negative regulation of catalytic activity
regulation of catalytic activity
regulation of protein phosphatase type 2A activity
positive regulation of glucose import
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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