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SPP/Signal Peptide Peptidase Polyclonal Antibody
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FIGURE: 1 / 1
SPP/Signal Peptide Peptidase Antibody (BS-11178R) in ELISA
Antigen: bs-11178P, 2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Rabbit Anti-Goat IgG(bs-0294R-HRP) at 1:5000; TMB staining Read the data in Microplate Reader by 450nm.
Product Details
BS-11178R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Signal Peptide Peptidase, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hIMP1; histocompatibility (minor) 13 isoform HM13_1; histocompatibility (minor) 13 isoform HM13_2; histocompatibility 13; hPSRP; IMP-1; IMPAS; Intramembrane protease 1; minor histocompatibility antigen 13; Minor histocompatibility antigen H13; presenilin-like aspartyl protease; Presenilin-like protein 3; Signal peptide peptidase; signal peptide peptidase beta; signal peptide peptidase like 1; Signal peptide peptidase-like 1; SPP beta; unnamed protein product
Gene Aliases: 1200006O09Rik; 4930443L17Rik; 5031424B04Rik; AV020344; H-13; H13; HM13; IMP1; IMPAS; IMPAS-1; MSTP086; PSENL3; PSL3; SPP; SPPL1
UniProt ID: (Mouse) Q8HWA9, (Human) Q8TCT9
Entrez Gene ID: (Mouse) 14950, (Human) 81502, (Rat) 311545
proteolysis
membrane protein proteolysis
in utero embryonic development
signal peptide processing
membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
cellular response to oxidative stress
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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