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Invitrogen
CD3d Polyclonal Antibody
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FIGURE: 1 / 4
CD3d Antibody (PA5-102404) in IHC (P)
Immunohistochemistry analysis of CD3d in human kidney cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with CD3d polyclonal antibody (Product # PA5-102404) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102404
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CD3D(Accession P04234), corresponding to amino acid residues I108-A158.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CD3D.
Target Information
CD3d is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The CD3d protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in the CD3d gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms of CD3d have been found. Other variants of CD3d may also exist, but the full-length nature of their transcripts have yet to be defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD3 antigen delta polypeptide; CD3 antigen, delta subunit; CD3 delta; CD3 molecule delta polypeptide; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); OKT3, delta chain; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain; unnamed protein product
Gene Aliases: CD3-DELTA; CD3D; CD3DELTA; IMD19; T3D
UniProt ID: (Human) P04234, (Mouse) P04235, (Rat) P19377
Entrez Gene ID: (Human) 915, (Mouse) 12500, (Rat) 25710
adaptive immune response
immune system process
cell surface receptor signaling pathway
positive thymic T cell selection
alpha-beta T cell activation
T cell receptor signaling pathway
protein complex assembly
T cell activation
biological_process
T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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