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OriGene
SETD7 Monoclonal Antibody (OTI2E3), TrueMAB™
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Product Details
CF503377
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2E3
Immunogen
Full length human recombinant protein of human SETD7 produced in HEK293 cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Lysine N-methyltransferase 7; OTTHUMP00000220049; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; SET7; SET7/9; SET9
Gene Aliases: 1600028F23Rik; H3K4MT; KIAA1717; KMT7; mKIAA1717; SET7; SET7/9; SET9; SETD7
UniProt ID: (Human) Q8WTS6, (Mouse) Q8VHL1
Entrez Gene ID: (Human) 80854, (Mouse) 73251
p53 binding
chromatin binding
protein binding
methyltransferase activity
protein-lysine N-methyltransferase activity
transferase activity
histone methyltransferase activity
histone H3 methyltransferase activity
histone H3K4 monomethyltransferase activity
histone-lysine N-methyltransferase activity
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
regulation of DNA repair
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
peptidyl-lysine monomethylation
peptidyl-lysine dimethylation
methylation
response to ethanol
positive regulation of transcription, DNA-templated
heterochromatin organization
response to alcohol
transcription, DNA-templated
chromatin modification
peptidyl-lysine methylation
histone lysine methylation
negative regulation of transferase activity
regulation of histone H3-K9 methylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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