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OriGene
TMEM173 Monoclonal Antibody (OTI4H8), TrueMAB™
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Product Details
CF505024
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI4H8
Immunogen
Full length human recombinant protein of human TMEM173 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; membrane protein; mitochondrial mediator of IRF3 activation; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; Stimulator of interferon genes protein; stimulator of interferon protein; stimulator of interferon response cGAMP interactor-deltaC; stimulator of interferon response cGAMP interactor-deltaN; sting 1; STING-deltaC; STING-deltaN; tm173; Transmembrane protein 173; transmembrane protein 173; TMEM173; unnamed protein product
Gene Aliases: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING-beta; STING1; TMEM173
UniProt ID: (Human) Q86WV6
Entrez Gene ID: (Human) 340061
nucleotide binding
transcription coactivator activity
protein binding
hydrogen ion channel activity
protein kinase binding
ubiquitin protein ligase binding
cyclic-di-GMP binding
signaling adaptor activity
identical protein binding
protein homodimerization activity
cyclic-GMP-AMP binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
protein serine/threonine kinase binding
autophagosome assembly
activation of innate immune response
pattern recognition receptor signaling pathway
positive regulation of defense response to virus by host
immune system process
cytoplasmic pattern recognition receptor signaling pathway
ion transport
autophagy
regulation of gene expression
positive regulation of macroautophagy
regulation of metabolic process
signal transduction involved in regulation of gene expression
positive regulation of type I interferon production
protein exit from endoplasmic reticulum
positive regulation of interferon-beta production
ion transmembrane transport
cellular response to interferon-beta
innate immune response
positive regulation of transcription from RNA polymerase II promoter
regulation of inflammatory response
protein oligomerization
defense response to virus
positive regulation of type I interferon-mediated signaling pathway
reticulophagy
protein localization to endoplasmic reticulum
cellular response to exogenous dsRNA
antiviral innate immune response
cGAS/STING signaling pathway
positive regulation of cGAS/STING signaling pathway
positive regulation of cytokine production involved in inflammatory response
hydrogen ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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