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OriGene
TGM2 Monoclonal Antibody (OTI2F9), TrueMAB™
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Product Details
CF809187
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2F9
Immunogen
Full length human recombinant protein of human TGM2 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C polypeptide, protein-glutamine-gamma-glutamyltransferase; crosslinker; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; RP5-1054A22.2; TG(C); TG2; TGase C; TGase H; TGase II; TGase-2; TGase-H; Tissue transglutaminase; Tissue type transglutaminase; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG; tTgase; unnamed protein product
Gene Aliases: G(h); hTG2; TG(C); TGC; TGM2; tTG
UniProt ID: (Human) P21980
Entrez Gene ID: (Human) 7052
nucleotide binding
protein-glutamine gamma-glutamyltransferase activity
calcium ion binding
protein binding
GTP binding
peptidase activity
transferase activity
transferase activity, transferring acyl groups
hydrolase activity
metal ion binding
protein-glutamine glutaminase activity
peptide serotonyltransferase activity
histone serotonyltransferase activity
peptide dopaminyltransferase activity
histone dopaminyltransferase activity
peptide noradrenalinyltransferase activity
peptide histaminyltransferase activity
chromatin remodeling
proteolysis
phospholipase C-activating G-protein coupled receptor signaling pathway
gene expression
dopamine secretion
peptide cross-linking
protein deamination
negative regulation of endoplasmic reticulum calcium ion concentration
regulation of apoptotic process
positive regulation of apoptotic process
apoptotic cell clearance
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of neurogenesis
positive regulation of small GTPase mediated signal transduction
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
bone development
branching involved in salivary gland morphogenesis
salivary gland cavitation
cellular response to cocaine
cellular response to dopamine
positive regulation of sprouting angiogenesis
cellular response to serotonin
regulation of apoptotic cell clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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