Proteintech

RPS3 Monoclonal Antibody (2G7H4), CoraLite® Plus 488

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Product Details

CL488-66046

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

2G7H4

Immunogen

Full length RPS3 protein.

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Target Information

WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR-90 ribosomal protein S3; MGC87870; OTTHUMP00000229804; OTTHUMP00000229805; OTTHUMP00000229874; OTTHUMP00000229877; OTTHUMP00000229878; OTTHUMP00000229879; OTTHUMP00000229880; OTTHUMP00000229882; OTTHUMP00000229883; OTTHUMP00000229886; Small ribosomal subunit protein uS3

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Gene Aliases: D7Ertd795e; OK/SW-cl.26; RPS3; Rs_3; S3

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UniProt ID: (Human) P23396, (Mouse) P62908, (Rat) P62909

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Entrez Gene ID: (Human) 6188, (Mouse) 27050, (Rat) 140654

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Function(s)
DNA binding damaged DNA binding RNA binding mRNA binding structural constituent of ribosome DNA-(apurinic or apyrimidinic site) lyase activity endodeoxyribonuclease activity protein binding microtubule binding transcription factor binding tubulin binding DNA N-glycosylase activity enzyme binding kinase binding protein kinase binding Hsp70 protein binding SUMO binding oxidized purine DNA binding oxidized pyrimidine DNA binding ubiquitin-like protein conjugating enzyme binding poly(A) RNA binding protein kinase A binding iron-sulfur cluster binding Hsp90 protein binding small ribosomal subunit rRNA binding supercoiled DNA binding nucleic acid binding oxidized purine nucleobase lesion DNA N-glycosylase activity lyase activity NF-kappaB binding ribosomal protein
Process(es)
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay DNA repair transcription, DNA-templated regulation of transcription, DNA-templated rRNA processing translation translational initiation SRP-dependent cotranslational protein targeting to membrane apoptotic process cellular response to DNA damage stimulus response to oxidative stress chromosome segregation mitotic nuclear division positive regulation of gene expression negative regulation of translation viral transcription positive regulation of microtubule polymerization negative regulation of protein ubiquitination positive regulation of endodeoxyribonuclease activity DNA damage response, detection of DNA damage regulation of apoptotic process positive regulation of JUN kinase activity negative regulation of DNA repair positive regulation of DNA repair spindle assembly cell division response to TNF agonist cellular response to hydrogen peroxide positive regulation of NIK/NF-kappaB signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of DNA N-glycosylase activity positive regulation of base-excision repair positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis DNA metabolic process regulation of translation cell cycle positive regulation of NF-kappaB transcription factor activity nucleic acid phosphodiester bond hydrolysis DNA catabolic process, endonucleolytic cytoplasmic translation
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