Search
Proteintech
MFSD2 Monoclonal Antibody (2D2B4), CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
CL488-67965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2D2B4
Immunogen
MFSD2 fusion protein Ag31028
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AGYQTRGCS QPERVKFTLN MLVTMAPIVL ILLGLLLFKM YPIDEERRRQ NKKALQALRD EASSSGCSET DSTELASIL
Target Information
Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HsMFSD2A; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2A; Major facilitator superfamily domain-containing protein 2A; Mfsd2a; NLS1; sodium-dependent LPC symporter 1; Sodium-dependent lysophosphatidylcholine symporter 1; unnamed protein product; zgc:101615
Gene Aliases: 1700018O18Rik; HMFN0656; HsMFSD2A; MCPH15; MFSD2; MFSD2A; NEDMISBA; NLS1; PP9177; SLC59A1; UNQ300/PRO341
UniProt ID: (Human) Q8NA29, (Mouse) Q9DA75
Entrez Gene ID: (Human) 84879, (Mouse) 76574
transport
lipid transport
fatty acid transport
phospholipid transport
transcytosis
transmembrane transport
establishment of blood-brain barrier
lipid transport across blood brain barrier
retinal pigment epithelium development
phosphatidylcholine biosynthetic process
brain development
photoreceptor cell morphogenesis
carbohydrate transport
cellular response to starvation
positive regulation of triglyceride biosynthetic process
long-chain fatty acid transport
hippocampus development
positive regulation of cell growth
negative regulation of fatty acid beta-oxidation
lipid translocation
very-low-density lipoprotein particle assembly
maintenance of blood-brain barrier
photoreceptor cell outer segment organization
regulation of multicellular organism growth
regulation of dendrite development
cognition
lysophospholipid transport
retina morphogenesis in camera-type eye
motor behavior
energy homeostasis
lysophospholipid translocation
regulation of neuron projection arborization
transport across blood-brain barrier
regulation of phosphatidylcholine metabolic process
regulation of phosphatidylethanolamine metabolic process
regulation of phosphatidylserine metabolic process
embryonic brain development
establishment of blood-retinal barrier
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support