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Proteintech
FH Monoclonal Antibody (1A9C8), CoraLite® Plus 488
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Product Details
CL488-68162
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1A9C8
Immunogen
FH fusion protein Ag30254
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: HEVLLPGLQ KLHDALDAKS KEFAQIIKIG RTHTQDAVPL TLGQEFSGYV QQVKYAMTRI KAAMPRIYEL AAGGTAVGTG LNTRIGFAEK VAAKVAALTG LPFVTAPNKF EALAAHDALV ELSGAMNTTA CSLMKIANDI RFLGSGPRSG LGELILPENE PGSSIMPGKV NPTQCEAMTM VAAQVMGNHV AVTVGGSNGH FELNVFKPMM IKNVLHSARL LGDASVSFTE NCVVGIQANT ERINKLMNES LMLVTALNPH IGYDKAAKIA KTAHKNGSTL KETAIELGYL TAEQFDEWVK PKDMLGPK
Target Information
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EF-3; epididymis secretory sperm binding protein; Fumarase; fumarase precursor (EC 4.2.1.2); fumarate hydratase 1; Fumarate hydratase, mitochondrial; unnamed protein product
Gene Aliases: FH; Fh-1; Fh1; FMRD; Fumarase; HLRCC; HsFH; LRCC; MCL; MCUL1
UniProt ID: (Human) P07954, (Pig) P10173, (Rat) P14408, (Mouse) P97807
Entrez Gene ID: (Human) 2271, (Pig) 100627128, (Rabbit) 100357596, (Rat) 24368, (Mouse) 14194
urea cycle
regulation of arginine metabolic process
tricarboxylic acid cycle
fumarate metabolic process
malate metabolic process
DNA repair
arginine metabolic process
cellular response to DNA damage stimulus
homeostasis of number of cells within a tissue
positive regulation of cold-induced thermogenesis
positive regulation of double-strand break repair via nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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