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PTGER4 Monoclonal Antibody (4A2A12), CoraLite® 594

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PTGER4 Monoclonal Antibody (4A2A12), CoraLite® 594

Product Details

CL59466921100UL

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

4A2A12

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EP1; G-protein coupled receptor; PTGER4; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; prostaglandin E2 receptor type 4; Prostanoid EP4 receptor

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Gene Aliases: EP4; EP4R; Ptger; PTGER2; PTGER4; Ptgerep4

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UniProt ID: (Human) P35408, (Mouse) P32240, (Rat) O08728

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Entrez Gene ID: (Pig) 100625072, (Human) 5734, (Mouse) 19219, (Rat) 84023

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Function(s)
G-protein coupled receptor activity prostaglandin receptor activity prostaglandin E receptor activity protein binding signal transducer activity G-protein coupled receptor
Process(es)
MAPK cascade negative regulation of cytokine production positive regulation of cytokine production inflammatory response immune response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration JNK cascade response to mechanical stimulus negative regulation of integrin activation response to lipid response to prostaglandin E T-helper cell differentiation negative regulation of inflammatory response positive regulation of inflammatory response regulation of stress fiber assembly bone development ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to prostaglandin E stimulus negative regulation of eosinophil extravasation intestine smooth muscle contraction positive regulation of smooth muscle cell migration regulation of ossification positive regulation of cAMP biosynthetic process response to lipopolysaccharide positive regulation of interleukin-8 production positive regulation of urine volume positive regulation of renal sodium excretion positive regulation of bone resorption negative regulation of cytokine secretion positive regulation of cytokine secretion negative regulation of oxidoreductase activity positive regulation of mucus secretion ductus arteriosus closure positive regulation of hyaluronan biosynthetic process positive regulation of ovarian follicle development positive regulation of antral ovarian follicle growth positive regulation of neutrophil extravasation negative regulation of peroxidase activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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