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Proteintech
PTGER4 Monoclonal Antibody (4A2A12), CoraLite® Plus 488
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FIGURE: 1 / 1
PTGER4 Antibody (CL488-66921) in Flow
1x10^6 HepG2 cells were intracellularly stained with 0.8 µg CoraLite® Plus 488 Anti-Human PTGER4 (CL488-66921, Clone: 4A2A12) (red), or 0.8 µg CoraLite® Plus 488 Mouse IgG2b Isotype Control (MPC-11) (CL488-65128, Clone: MPC-11) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-66921
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4A2A12
Immunogen
PTGER4 fusion protein Ag19262
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RKTVLSKAI EKIKCLFCRI GGSRRERSGQ HCSDSQRTSS AMSGHSRSFI SRELKEISST SQTLLPDLSL PDLSENGLGG RNLLPGVPGM GLAQEDTTSL RTLRISETSD SSQGQDSESV LLVDEAGGSG RAGPAPKGSS LQVTFPSETL NLSEKCI
Target Information
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EP1; G-protein coupled receptor; PTGER4; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); Prostaglandin E2 receptor EP4 subtype; prostaglandin E2 receptor type 4; Prostanoid EP4 receptor
Gene Aliases: EP4; EP4R; Ptger; PTGER2; PTGER4; Ptgerep4
UniProt ID: (Human) P35408, (Mouse) P32240, (Rat) O08728
Entrez Gene ID: (Pig) 100625072, (Human) 5734, (Mouse) 19219, (Rat) 84023
MAPK cascade
negative regulation of cytokine production
positive regulation of cytokine production
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JNK cascade
response to mechanical stimulus
negative regulation of integrin activation
response to lipid
response to prostaglandin E
T-helper cell differentiation
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of stress fiber assembly
bone development
ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to prostaglandin E stimulus
negative regulation of eosinophil extravasation
intestine smooth muscle contraction
positive regulation of smooth muscle cell migration
regulation of ossification
positive regulation of cAMP biosynthetic process
response to lipopolysaccharide
positive regulation of interleukin-8 production
positive regulation of urine volume
positive regulation of renal sodium excretion
positive regulation of bone resorption
negative regulation of cytokine secretion
positive regulation of cytokine secretion
negative regulation of oxidoreductase activity
positive regulation of mucus secretion
ductus arteriosus closure
positive regulation of hyaluronan biosynthetic process
positive regulation of ovarian follicle development
positive regulation of antral ovarian follicle growth
positive regulation of neutrophil extravasation
negative regulation of peroxidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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