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Proteintech
GATA2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
11103-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GATA2 Fusion Protein Ag1557 (168-467 aa encoded by BC018988)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.36 mg/mL
Amount
54 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SHLFGFPPT PPKEVSPDPS TTGAASPASS SAGGSAARGE DKDGVKYQVS LTESMKMESG SPLRPGLATM GTQPATHHPI PTYPSYVPAA AHDYSSGLFH PGGFLGGPAS SFTPKQRSKA RSCSEGRECV NCGATATPLW RRDGTGHYLC NACGLYHKMN GQNRPLIKPK RRLTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG (168-467 aa encoded by BC018988)
Target Information
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ45948; GATA-bindning protein 2; MGC2306; unnamed protein product
Gene Aliases: DCML; Gata-2; IMD21; MONOMAC; NFE1B
UniProt ID: (Human) P23769, (Rat) Q924Y4, (Mouse) O09100
Entrez Gene ID: (Human) 2624, (Rat) 25159, (Mouse) 14461
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
C2H2 zinc finger domain binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
cell fate determination
neuron migration
embryonic placenta development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cytosolic calcium ion concentration
positive regulation of gene expression
negative regulation of gene expression
regulation of primitive erythrocyte differentiation
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
cell differentiation
neuron differentiation
response to lipid
somatic stem cell population maintenance
eosinophil fate commitment
inner ear morphogenesis
positive regulation of mast cell degranulation
positive regulation of blood vessel endothelial cell migration
cell fate commitment
fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
cell maturation
animal organ development
neuron fate commitment
homeostasis of number of cells within a tissue
positive regulation of phagocytosis
regulation of developmental process
positive regulation of phagocytosis, engulfment
definitive hemopoiesis
semicircular canal development
vascular wound healing
positive regulation of cell migration involved in sprouting angiogenesis
cochlea development
GABAergic neuron differentiation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
negative regulation of endothelial cell apoptotic process
regulation of forebrain neuron differentiation
anatomical structure morphogenesis
positive regulation of transcription, DNA-templated
system development
regulation of multicellular organismal process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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