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Fabgennix
GTP cyclohydrolase 1 Polyclonal Antibody, Biotin
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Product Details
GTPCH1-1-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
N-epitope synthetic peptide taken within amino acid region 1-50 on GTPCHI protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternative splice form; dystonia 14; GCH1; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I; guanosine 5'-triphosphate cyclohydrolase I
Gene Aliases: DYT14; DYT5; DYT5a; GCH; GCH1; GTP-CH; GTP-CH-1; GTPCH; GTPCH1; HPABH4B
UniProt ID: (Human) P30793, (Mouse) Q05915, (Rat) P22288
Entrez Gene ID: (Human) 2643, (Mouse) 14528, (Rat) 29244
nucleotide binding
catalytic activity
GTPase activity
GTP cyclohydrolase I activity
protein binding
GTP binding
zinc ion binding
hydrolase activity
identical protein binding
protein homodimerization activity
metal ion binding
mitogen-activated protein kinase binding
calcium ion binding
GTP-dependent protein binding
coenzyme binding
hydrolase
metabolite interconversion enzyme
tetrahydrobiopterin biosynthetic process
nitric oxide biosynthetic process
regulation of blood pressure
positive regulation of heart rate
regulation of lung blood pressure
response to lipopolysaccharide
response to interferon-gamma
response to tumor necrosis factor
dopamine biosynthetic process
pteridine-containing compound metabolic process
pteridine-containing compound biosynthetic process
tetrahydrobiopterin metabolic process
tetrahydrofolate biosynthetic process
response to pain
neuromuscular process controlling posture
positive regulation of nitric-oxide synthase activity
regulation of removal of superoxide radicals
protein complex assembly
metabolic process
vasodilation
negative regulation of blood pressure
dihydrobiopterin metabolic process
protein homooligomerization
protein heterooligomerization
7,8-dihydroneopterin 3'-triphosphate biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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