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NR2E1 Polyclonal Antibody, MaxPab™

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NR2E1 Polyclonal Antibody, MaxPab™

Product Details

H00007101-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NR2E1 (NP_003260.1, 1 a.a. approximately 385 a.a) full-length human protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY VCKSGNQGGC PVDKTHRNQC RACRLKKCLE VNMNKDAVQH ERGPRTSTIR KQVALYFRGH KEENGAAAHF PSAALPAPAF FTAVTQLEPH GLELAAVSTT PERQTLVSLA QPTPKYPHEV NGTPMYLYEV ATESVCESAA RLLFMSIKWA KSVPAFSTLS LQDQLMLLED AWRELFVLGI AQWAIPVDAN TLLAVSGMNG DNTDSQKLNK IISEIQALQE VVARFRQLRL DATEFACLKC IVTFKAVPTH SGSELRSFRN AAAIAALQDE AQLTLNSYIH TRYPTQPCRF GKLLLLLPAL RSISPSTIEE VFFKKTIGNV PITRLLSDMY KSSDI

Target Information

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HTll; NR2E1; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog; similar to Drosophila tailless; tailes-related receptor; tailless; Tll; TLX; unnamed protein product

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Gene Aliases: NR2E1; TLL; TLX; XTLL

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UniProt ID: (Human) Q9Y466

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Entrez Gene ID: (Human) 7101

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding enzyme binding histone deacetylase binding sequence-specific DNA binding metal ion binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis behavioral fear response positive regulation of neuroblast proliferation aggressive behavior regulation of transcription, DNA-templated apoptotic process nervous system development neuroblast proliferation brain development visual perception cell proliferation positive regulation of cell proliferation dentate gyrus development amygdala development olfactory bulb development layer formation in cerebral cortex forebrain generation of neurons cerebral cortex neuron differentiation central nervous system neuron differentiation anterior commissure morphogenesis cerebral cortex development cell differentiation extracellular matrix organization intracellular steroid hormone receptor signaling pathway intracellular receptor signaling pathway somatic stem cell population maintenance social behavior camera-type eye development negative regulation of apoptotic process astrocyte cell migration cell fate commitment negative regulation of neuron differentiation positive regulation of angiogenesis positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter astrocyte differentiation negative regulation of astrocyte differentiation regulation of dendrite morphogenesis regulation of cellular component organization retina development in camera-type eye regulation of timing of neuron differentiation long-term synaptic potentiation neural precursor cell proliferation regulation of cell migration involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation
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