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Invitrogen
CD80 Monoclonal Antibody (MEM-233)
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FIGURE: 1 / 2
CD80 Antibody (MA1-19215) in Flow
Flow Cytometry analysis of CD80 using CD80 Monoclonal Antibody (MEM-233) (Product # MA1-19215). Separation of CD80 transfected P815 cells stained using anti-human CD80 (MEM-233) purified antibody (concentration in sample 1.67 μg/mL, GAM APC, red-filled) from CD80 transfected P815 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).
Product Details
MA1-19215
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MEM-233
Immunogen
Extracellular domain of human CD80 fused to human IgG1(Fc).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activation B7-1 antigen; B-lymphocyte activation antigen B7; B7; BB1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; s1CD80; s2CD80; sCD 80; sCD80; soluble CD 80; soluble CD80; T-lymphocyte activation antigen CD80; transmembrane protein B1 precursor; TS/A-1; unnamed protein product
Gene Aliases: B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; CD80; LAB7
UniProt ID: (Human) P33681
Entrez Gene ID: (Human) 941
immune system process
regulation of immune system process
negative regulation of T cell mediated immunity
immune response
cell surface receptor signaling pathway
positive regulation of signal transduction
T cell costimulation
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interleukin-2 production
intracellular signal transduction
positive regulation of T cell proliferation
T cell activation
negative regulation of T cell proliferation
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription, DNA-templated
viral entry into host cell
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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