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Invitrogen
CD80 Monoclonal Antibody (MEM-233), APC
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FIGURE: 1 / 1
CD80 Antibody (MA1-19464) in Flow
Separation of CD80+ transfected P815 cells (red-filled) from P815 cells (black-dashed) in flow cytometry analysis (surface staining) stained using anti-human CD80 (MEM-233) APC Monoclonal antibody (Product # MA1-19464) (10 µL reagent per milion cells in 100 µL of cell suspension).
Product Details
MA1-19464
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MEM-233
Immunogen
Extracellular domain of human CD80 fused to human IgG1 (Fc)
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
0.035 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activation B7-1 antigen; B-lymphocyte activation antigen B7; B7; BB1; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; s1CD80; s2CD80; sCD 80; sCD80; soluble CD 80; soluble CD80; T-lymphocyte activation antigen CD80; transmembrane protein B1 precursor; TS/A-1; unnamed protein product
Gene Aliases: B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; CD80; LAB7
UniProt ID: (Human) P33681
Entrez Gene ID: (Human) 941
immune system process
regulation of immune system process
negative regulation of T cell mediated immunity
immune response
cell surface receptor signaling pathway
positive regulation of signal transduction
T cell costimulation
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interleukin-2 production
intracellular signal transduction
positive regulation of T cell proliferation
T cell activation
negative regulation of T cell proliferation
positive regulation of T-helper 1 cell differentiation
positive regulation of transcription, DNA-templated
viral entry into host cell
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to lipopolysaccharide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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