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Invitrogen

Aquaporin 1 Monoclonal Antibody (7D11)

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Aquaporin 1 Monoclonal Antibody (7D11)

Product Details

MA1-24915

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

1:1,000-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

7D11

Immunogen

Synthetic peptide corresponding to amino acids 198-208 of rat aquaporin 1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Protein G

Storage buffer

PBS with 0.1% BSA

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2057160

Product Specific Information

Predicted moleuclar weight is 32.28 kDa by western blot. Possible positive control for MA1-24915 is kidney tissue.

Target Information

Aquaporin 1 is a 28kD integral membrane protein which was originally identified in red blood cells and renal proximal tubules. AQP1 is also expressed by the choroid plexus and various other tissues. It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 28 kda erythrocyte integral membrane protein homolog; AQP 1; AQP CHIP; AQP-1; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group); aquaporin 1, Colton blood group antigen; Aquaporin CHIP; Aquaporin-1; Aquaporin-CHIP; Aquaporin1; bloodgroup CO protein; Channel-like integral membrane protein of 28 kDa; channel-like integral membrane protein, 28-kDa; CHIP 28; Colton blood group; Colton blood group antigen; Delayed early response protein 2; DER2; growth factor-induced delayed early response protein; MGC26324; unnamed protein product; Urine water channel; water channel protein for red blood cells and kidney proximal tubule

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Gene Aliases: AQP-CHIP; AQP1; CHIP28; CO

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UniProt ID: (Human) P29972, (Mouse) Q02013, (Rat) P29975

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Entrez Gene ID: (Human) 358, (Mouse) 11826, (Rat) 25240

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Function(s)
intracellular cGMP activated cation channel activity potassium channel activity water transmembrane transporter activity protein binding ammonium transmembrane transporter activity potassium ion transmembrane transporter activity glycerol transmembrane transporter activity water channel activity channel activity transmembrane transporter activity nitric oxide transmembrane transporter activity carbon dioxide transmembrane transporter activity identical protein binding ephrin receptor binding hydrogen peroxide channel activity transporter activity glycerol channel activity transporter
Process(es)
renal water homeostasis glomerular filtration renal water transport potassium ion transport water transport cell volume homeostasis hyperosmotic response cellular water homeostasis fibroblast migration positive regulation of fibroblast migration carbon dioxide transport glycerol transport cell migration sensory perception of pain cellular homeostasis cGMP-mediated signaling lateral ventricle development pancreatic juice secretion nitric oxide transport establishment or maintenance of actin cytoskeleton polarity secretion by cell cerebrospinal fluid secretion secretory granule organization cellular response to UV transepithelial water transport carbon dioxide transmembrane transport wound healing odontogenesis negative regulation of apoptotic process lipid digestion positive regulation of angiogenesis positive regulation of saliva secretion positive regulation of fibroblast proliferation camera-type eye morphogenesis defense response to Gram-negative bacterium multicellular organismal water homeostasis corticotropin secretion establishment of localization in cell transmembrane transport renal water absorption cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to copper ion cellular response to mercury ion cellular response to retinoic acid cellular response to cAMP cellular response to hypoxia cellular response to salt stress cellular hyperosmotic response cellular response to dexamethasone stimulus cellular response to nitric oxide potassium ion transmembrane transport metanephric descending thin limb development metanephric proximal straight tubule development metanephric proximal convoluted tubule segment 2 development metanephric glomerulus vasculature development ammonium transmembrane transport hydrogen peroxide transmembrane transport cation transmembrane transport cGMP biosynthetic process transport positive regulation of lamellipodium assembly positive regulation of epithelial cell migration organic cation transport ammonium transport water homeostasis positive regulation of cell migration cellular response to stress carbohydrate transmembrane transport response to drug negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to inorganic substance maintenance of symbiont-containing vacuole by host response to hormone hyperosmotic salinity response response to estrogen
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