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Invitrogen
POLE Monoclonal Antibody (93H3A)
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Product Details
MA5-13616
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
93H3A
Immunogen
Purified recombinant human DNA polymerase epsilon corresponding to aa1-176
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13616 targets DNA Polymerase epsilon in IP and WB applications and shows reactivity with Bovine, Human, mouse, and Non-human primate samples.
The MA5-13616 immunogen is purified recombinant human DNA polymerase epsilon corresponding to aa1-176.
Target Information
POLE (Polepsi) is present in proliferating cells and is implicated in repair of UV-damaged DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3'-5' exodeoxyribonuclease; DNA polymerase epsilon catalytic subunit A; DNA polymerase epsilon catalytic subunit protein; DNA polymerase II subunit A; DNA-directed DNA polymerase epsilon; pol-epsilon; polymerase (DNA directed), epsilon, catalytic subunit; polymerase (DNA) epsilon, catalytic subunit; unnamed protein product
Gene Aliases: CRCS12; FILS; IMAGEI; POLE; POLE1
UniProt ID: (Human) Q07864, (Mouse) Q9WVF7
Entrez Gene ID: (Bovine) 785457, (Human) 5426, (Mouse) 18973
nucleotide binding
nucleic acid binding
DNA binding
chromatin binding
DNA-directed DNA polymerase activity
protein binding
zinc ion binding
single-stranded DNA 3'-5' exodeoxyribonuclease activity
transferase activity
nucleotidyltransferase activity
hydrolase activity
DNA polymerase activity
metal ion binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
3'-5' exonuclease activity
DNA metabolism protein
G1/S transition of mitotic cell cycle
mitotic cell cycle
DNA synthesis involved in DNA repair
DNA replication
DNA-dependent DNA replication
leading strand elongation
DNA repair
base-excision repair, gap-filling
nucleotide-excision repair, DNA gap filling
cellular response to DNA damage stimulus
DNA replication proofreading
embryonic organ development
DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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