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Invitrogen
CK1 epsilon Monoclonal Antibody (OTI2B3)
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FIGURE: 1 / 5
CK1 epsilon Antibody (MA5-26623) in WB
Western blot was performed using Anti-CK1 epsilon Monoclonal Antibody (OTI2B3) (Product # MA5-26623) and a 47 kDa band corresponding to CK1 epsilon was observed across all the cell lines and tissues tested. Whole cell extracts (30 µg lysate) of U-87 MG (Lane 1), HeLa (Lane 2), MDA-MB-231 (Lane 3), HEK-293 (Lane 4), Jurkat (Lane 5), NIH/3T3 (Lane 6), PC-12 (Lane 7), tissue extracts of Mouse Brain (Lane 8) and Rat Brain (Lane 9) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then t... View More
Product Details
MA5-26623
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2B3
Immunogen
Human recombinant protein fragment corresponding to amino acids 153-416 of CSNK1E produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis. CSNK1E phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 1; Casein kinase I isoform epsilon; CK1e; CKI-epsilon; CSNK1E; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1
Gene Aliases: CKIe; CKIepsilon; CSNK1E; HCKIE
UniProt ID: (Human) P49674
Entrez Gene ID: (Human) 1454
DNA repair
protein phosphorylation
endocytosis
signal transduction
protein localization
regulation of Wnt signaling pathway
positive regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
circadian regulation of gene expression
non-canonical Wnt signaling pathway
regulation of circadian rhythm
rhythmic process
circadian behavior
negative regulation of small GTPase mediated signal transduction
canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of beta-amyloid formation
cellular response to nerve growth factor stimulus
positive regulation of non-canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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