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Invitrogen

Pan SHANK Monoclonal Antibody (N23b/49)

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Pan SHANK Monoclonal Antibody (N23b/49)

Product Details

MA5-27633

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-Dependent
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N23b/49

Immunogen

Fusion protein amino acids 84-309 of rat Shank2
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735302

Product Specific Information

1 µg/mL of MA5-27633 was sufficient for detection of Shank1-4 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 160kDa. Recognizes Shank1, 2 and 3.

Target Information

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain specific protein; brain-specific protein; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; multidomain postsynaptic density protein; PDZ-based scaffold protein; ProSAP1 protein; postsynaptic density protein; postsynaptic scaffold protein; proline rich synapse associated protein 2; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; proline-rich synapse-associated protein 2; SAPAP-interacting protein synamon; scaffolding protein; SH3 and multiple ankyrin repeat domains protein 2-like; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; Shank2; shank3 postsynaptic density protein; somatostatin receptor-interacting protein; SPANK-1; SPANK-2; proSAP2; proline-rich synapse-associated protein 2; SSTR-interacting protein; synamon; unnamed protein product

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Gene Aliases: AUTS17; CORTBP1; CTTNBP1; DEL22q13.3; mKIAA1022; ProSAP1; PROSAP2; PSAP2; SCZD15; SHANK; Shank1a; Shank2E; SPANK-1; SPANK-2; SPANK-3; Spank1; SSTRIP; synamon

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UniProt ID: (Human) Q9Y566, (Human) Q9UPX8, (Human) Q9BYB0, (Rat) Q9WV48, (Mouse) D3YZU1, (Mouse) Q80Z38, (Rat) Q9QX74, (Rat) Q9JLU4, (Mouse) Q4ACU6

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Entrez Gene ID: (Human) 50944, (Human) 22941, (Human) 85358, (Rat) 78957, (Mouse) 243961, (Mouse) 210274, (Rat) 171093, (Rat) 59312, (Mouse) 58234

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Function(s)
G-protein coupled receptor binding protein binding SH3 domain binding receptor signaling complex scaffold activity GKAP/Homer scaffold activity somatostatin receptor binding ionotropic glutamate receptor binding identical protein binding macromolecular complex binding ankyrin repeat binding scaffold protein binding structural constituent of postsynaptic density zinc ion binding receptor binding
Process(es)
long-term memory associative learning adult behavior negative regulation of actin filament bundle assembly social behavior protein localization to synapse olfactory behavior habituation modulation of synaptic transmission synapse organization neuromuscular process controlling balance determination of affect righting reflex synapse maturation dendritic spine morphogenesis positive regulation of dendritic spine development protein-containing complex assembly vocalization behavior AMPA selective glutamate receptor signaling pathway maintenance of postsynaptic density structure positive regulation of excitatory postsynaptic potential synapse assembly learning memory positive regulation of cell proliferation adult locomotory behavior response to xenobiotic stimulus negative regulation of hippo signaling exploration behavior positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation long term synaptic depression regulation of postsynapse organization MAPK cascade embryonic epithelial tube formation learning or memory locomotory behavior gene expression glial cell proliferation striatal medium spiny neuron differentiation locomotory exploration behavior locomotion vocal learning negative regulation of cell volume regulation of synaptic plasticity positive regulation of long-term neuronal synaptic plasticity brain morphogenesis sensory perception of touch positive regulation of synapse structural plasticity regulation of dendritic spine morphogenesis neural precursor cell proliferation postsynaptic density assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering response to interleukin-17 regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of glutamate receptor signaling pathway regulation of long term synaptic depression regulation of AMPA glutamate receptor clustering regulation of grooming behavior regulation of behavioral fear response cognition response to nutrient
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