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Pan SHANK Monoclonal Antibody (N23b/49), FITC

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Pan SHANK Monoclonal Antibody (N23b/49), FITC

Product Details

MA5-45439

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N23b/49

Immunogen

Fusion protein amino acids 84-309 of rat Shank2
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931893

Product Specific Information

1 µg/mL of MA5-45439 was sufficient for detection of Shank1-4 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 160kDa. Recognizes Shank1, 2 and 3.

Target Information

Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Studies suggest that Shank2 is expressed in the neurons of the developing retina, and could play a role in the neuronal differentiation of the developing retina. Other recent studies suggest that the disruption of glutamate receptors at the Shank postsynaptic platform could contribute to the destruction of the postsynaptic density, which underlies the synaptic dysfunction and loss in Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CortBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; multidomain postsynaptic density protein; PDZ-based scaffold protein; ProSAP1 protein; postsynaptic scaffold protein; proline rich synapse associated protein 1; proline rich synapse associated protein 2; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; Proline-rich synapse-associated protein 2; ProSAP1; ProSAP2; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3 and multiple ankyrin repeat domains protein 2; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 1; SH3/ankyrin domain gene 2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; Shank1; Shank2; Shank3; shank3 postsynaptic density protein; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; shank3e splice variant III; shank3e splice variant IV; Somatostatin receptor-interacting protein; SPANK-1; SPANK-2; SPANK-3; SSTR-interacting protein; Synamon

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Gene Aliases: AI841104; AUTS17; CORTBP1; CTTNBP1; DEL22q13.3; KIAA1022; KIAA1650; mKIAA1022; PROSAP1; PROSAP2; PSAP2; SCZD15; SHANK; SHANK1; Shank1a; SHANK2; SHANK3; Shank3b; SHANK3c-3; SHANK3c-4; SPANK-1; SPANK-2; SPANK-3; Spank1; SSTRIP; synamon

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UniProt ID: (Human) Q9Y566, (Human) Q9UPX8, (Human) Q9BYB0, (Rat) Q9WV48, (Mouse) D3YZU1, (Mouse) Q80Z38, (Rat) Q9QX74, (Mouse) Q4ACU6, (Rat) Q9JLU4

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Entrez Gene ID: (Human) 50944, (Human) 22941, (Human) 85358, (Rat) 78957, (Mouse) 243961, (Mouse) 210274, (Rat) 171093, (Mouse) 58234, (Rat) 59312

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Function(s)
G-protein coupled receptor binding protein binding SH3 domain binding receptor signaling complex scaffold activity GKAP/Homer scaffold activity somatostatin receptor binding ionotropic glutamate receptor binding identical protein binding macromolecular complex binding ankyrin repeat binding scaffold protein binding structural constituent of postsynaptic density actin binding zinc ion binding protein C-terminus binding protein complex binding protein self-association
Process(es)
MAPK cascade embryonic epithelial tube formation synapse assembly learning memory striatal medium spiny neuron differentiation adult behavior negative regulation of actin filament bundle assembly social behavior locomotory exploration behavior vocal learning negative regulation of cell volume positive regulation of long-term neuronal synaptic plasticity brain morphogenesis neuromuscular process controlling balance protein oligomerization positive regulation of synapse structural plasticity positive regulation of synaptic transmission, glutamatergic dendritic spine morphogenesis positive regulation of dendritic spine development regulation of dendritic spine morphogenesis vocalization behavior postsynaptic density assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering guanylate kinase-associated protein clustering regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of glutamate receptor signaling pathway regulation of long term synaptic depression positive regulation of excitatory postsynaptic potential regulation of grooming behavior regulation of behavioral fear response positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity associative learning synapse organization cognition exploration behavior long-term synaptic potentiation long term synaptic depression nervous system development long-term memory cell differentiation protein localization to synapse olfactory behavior habituation modulation of synaptic transmission determination of affect righting reflex synapse maturation protein-containing complex assembly AMPA selective glutamate receptor signaling pathway maintenance of postsynaptic density structure positive regulation of cell proliferation negative regulation of hippo signaling protein complex assembly cytoskeletal anchoring at plasma membrane regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity brain development response to nutrient
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